一种大鼠跑台抗阻训练模型的构建

doi:10.12300/j.issn.1674-5817.2020.089

实验动物与比较医学 ›› 2021, Vol. 41 ›› Issue (2): 143-147.DOI: 10.12300/j.issn.1674-5817.2020.089

所属专题：实验动物设施设备

• 论著:人类疾病动物模型 • 上一篇下一篇

一种大鼠跑台抗阻训练模型的构建

蔺海旗¹, 王震², 林文弢³

1.华南理工大学体育学院,广州 510641;
2.广东青年职业学院,广州 510550;
3.广州体育学院,广州 510500

出版日期:2021-04-25 发布日期:2021-04-30
作者简介:蔺海旗(1985—), 男, 博士研究生, 实验师, 研究方向: 运动健康促进。E-mail: sphqlin@scut.edu.cn
基金资助:
教育部人文社会科学研究青年基金项目(20YJCZH090); 广东省哲学社会科学“十三五”规划项目(GD19YTY01); 广东省教育科学“十三五”规划项目(2018GXJK001); 广州市哲学社会科学发展“十三五”规划2020年度项目(2020GZGJ37)

Establishment of a Resistance Training Model for Rats

LIN Haiqi¹, WANG Zhen², LIN Wentao³

1. School of Physical Education, South China University of Technology, Guangzhou 510641, China;
2. Guangdong Youth Vocational College, Guangzhou 510550, China;
3. Guangzhou Sports University, Guangzhou 510500, China

Online:2021-04-25 Published:2021-04-30

摘要/Abstract

摘要： 目的构建一种大鼠跑台抗阻训练模型。方法选用19月龄的雄性SD大鼠40只,通过测试确定跑台放置的角度和速度,并根据大鼠尾部负重负荷及全血乳酸的变化来确定抗阻训练模型的运动方案。结果大鼠在坡度35°跑台,以15 m/min跑速进行抗阻训练,运动效果较好。运动8~15 s时,全血乳酸浓度均值为3.8~5.2 mmol/L。根据能量代谢和全血乳酸半时反应情况,设定大鼠抗阻训练跑15 s、间歇30 s为一次训练。每组4次训练后全血乳酸浓度较为稳定;每组间歇3 min,每天3组,全血乳酸浓度为4~5 mmol/L。结论通过设置跑台的坡度、速度和大鼠尾部负重等参数,建立了一种大鼠跑台抗阻训练模型。

关键词: 大鼠, 抗阻训练, 动物跑台, 模型

Abstract: Objective This study discusses the construction of a resistance training model for rats using a treadmill. Methods A total of 40 male SD rats aged 19 months were selected to determine the conditions for the establishment of a resistance training model. To this end, the angle and speed of the treadmill were measured, the changes of the rat tail load and lactic acid levels in their blood were tested. Results Rats underwent resistance training on the treadmill at an incline of 35°and a running speed of 15 m/min, the exercise regimen significantly improved. After exercising for 8-15 s, the average blood lactic acid concentration was 3.8-5.2 mmol/L. According to the energy metabolism and blood lactic acid half-time response, the resistance training of rats was performed as one training session for 15 s and 30 s intervals. After 4 training sessions in each group, the blood lactic acid concentration was relatively stable. The blood lactic acid concentration was 4-5 mmol/L after resistance training for 3 groups per day and 3 min intervals between groups. Conclusion A resistance training model in rats is established based on the incline, speed of the rat treadmill, and the tail load of rats.

Key words: Rats, Resistance training, Treadmill, Model

中图分类号:

Q95-33
R-33

蔺海旗, 王震, 林文弢. 一种大鼠跑台抗阻训练模型的构建[J]. 实验动物与比较医学, 2021, 41(2): 143-147.

LIN Haiqi, WANG Zhen, LIN Wentao. Establishment of a Resistance Training Model for Rats[J]. Laboratory Animal and Comparative Medicine, 2021, 41(2): 143-147.

图/表 4

参考文献

[1] KOO J H, KANG E B, CHO J Y.Resistance exercise improves mitochondrial quality control in a rat model of sporadic inclusion body myositis[J]. Gerontology, 2019, 65(3):240-252. DOI:10.1159/000494723.
[2] BARBOSA M R, SHIGUEMOTO G E, TOMAZ L M, et al.Resistance training and ovariectomy: Antagonic effects in mitochondrial biogenesis markers in rat skeletal muscle[J]. Int J Sports Med, 2016, 37(11):841-848. DOI:10.1055/s-0042-107247.
[3] 胡敏, 邹亮畴, 刘承宜, 等. 大鼠抗阻训练模型的归类与分析[J]. 广州体育学院学报, 2009, 29(5):91-96. DOI:10.13830/j.cnki.cn44-1129/g8.2009.05.001.
[4] ATO S, KIDO K, SASE K, et al.Response of resistance exercise-induced muscle protein synthesis and skeletal muscle hypertrophy are not enhanced after disuse muscle atrophy in rat[J]. Front Physiol, 2020, 11:469. DOI:10.3389/fphys.2020.00469.
[5] 闫万军, 赵斌, 刘丰彬, 等. 负重跑训练对老龄大鼠肌肉丢失的影响[J]. 中国体育科技, 2009, 45(4):120-124. DOI:10.16470/j.csst.2009.04.001.
[6] MARQUETI R C, DURIGAN J L Q, OLIVEIRA A J S, et al. Effects of aging and resistance training in rat tendon remodeling[J]. FASEB J, 2018, 32(1):353-368. DOI:10.1096/fj.201700543r.
[7] 林文弢, 王震, 翁锡全, 等. 抗阻训练对衰老大鼠线粒体介导腓肠肌细胞凋亡通路相关因子表达影响的研究[J]. 中国运动医学杂志, 2014, 33(10):994-997. DOI:10.16038/j.1000-6710.2014.10.011.
[8] 王震, 林文弢, 翁锡全, 等. 抗阻训练对老龄大鼠腓肠肌Ca²+及线粒体膜电位的影响[J]. 广州体育学院学报, 2014, 34(2):85-88. DOI:10.13830/j.cnki.cn44-1129/g8.2014.02.024.
[9] WILLARDSON J M.A brief review: Factors affecting the length of the rest interval between resistance exercise sets[J]. J Strength Cond Res, 2006, 20(4):978-984. DOI:10.1519/R-17995.1.
[10] SABIDO R, HERN NDEZ-DAVÓJ L, CAPDEPON L, et al. How are mechanical, physiological, and perceptual variables affected by the rest interval between sets during a flywheel resistance session?[J]. Front Physiol, 2020, 11:663. DOI:10.3389/fphys.2020.00663.
[11] 冯钰, 程泽鹏, 史仍飞. 骨骼肌肥大动物模型的研究进展[J]. 中国体育科技, 2017, 53(6):79-84. DOI:10.16470/j.csst.201706009.
[12] 任飞, 胡敏, 潘慧文, 等. 一种新型大鼠抗阻训练模型的建立[J]. 实验动物科学, 2011, 28(1):52-53,59. DOI:10.3969/j.issn.1006-6179.2011.01.016.
[13] 苏艳红, 袁乾坤, 肖蓉, 等. 抗阻训练对增龄大鼠骨骼肌线粒体功能的影响[J]. 中国应用生理学杂志, 2020, 36(2):165-170,175. DOI:10.12047/j.cjap.5861.2020.037.
[14] 林文弢. 运动生物化学[M]. 北京: 高等教育出版社, 2019.
[15] NETO W K, CIENA A P, ANARUMA C A, et al.Vertical climbing for rodent resistance training: a discussion about training parameters[J]. Int J Sports Sci, 2016, 2016(61A):36-49. DOI:10.5923/s.sports.201601.07.
[16] CONSITT L A, DUDLEY C, SAXENA G.Impact of endurance and resistance training on skeletal muscle glucose metabolism in older adults[J]. Nutrients, 2019, 11(11):2636. DOI:10.3390/nu11112636.
[17] NICASTRO H, ZANCHI N E, DA LUZ C R, et al. An experimental model for resistance exercise in rodents[J]. J Biomed Biotechnol, 2012, 2012:457065. DOI:10.1155/2012/457065.
[18] DOS SANTOS J L, DANTAS R E, LIMA C A, et al. Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats[J]. J Int Soc Sports Nutr, 2014, 11(1):58. DOI:10.1186/s12970-014-0058-3.
[19] TAKEGAKI J, OGASAWARA R, KOTANI T, et al.Influence of shortened recovery between resistance exercise sessions on muscle-hypertrophic effect in rat skeletal muscle[J]. Physiol Rep, 2019, 7(13): e14155. DOI:10.14814/phy2.14155.
[20] TAVASSOLI H, HEIDARIANPOUR A, HEDAYATI M.The effects of resistance exercise training followed by de-training on irisin and some metabolic parameters in type 2 diabetic rat model[J]. Arch Physiol Biochem, 2019:1-8. DOI:10.1080/13813455.2019.1673432.

一种大鼠跑台抗阻训练模型的构建

Establishment of a Resistance Training Model for Rats

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