雄性不育药物研发相关实验动物模型建立和应用进展

doi:10.12300/j.issn.1674-5817.2023.120

实验动物与比较医学 ›› 2023, Vol. 43 ›› Issue (5): 504-511.DOI: 10.12300/j.issn.1674-5817.2023.120

雄性不育药物研发相关实验动物模型建立和应用进展

谢淑武()(), 沈如凌, 林金杏, 范春

上海实验动物研究中心, 上海 201203

收稿日期:2023-08-21 修回日期:2023-10-14 出版日期:2023-10-25 发布日期:2023-11-01
通讯作者: 谢淑武（1978—），男，博士，研究员，研究方向：生殖疾病模型构建与新药研发。E-mail：xieshw@fudan.edu.cn。ORCID： 0000-0001-5753-6824
作者简介:谢淑武（1978—），男，博士，研究员，研究方向：生殖疾病模型构建与新药研发。E-mail：xieshw@fudan.edu.cn。ORCID： 0000-0001-5753-6824
基金资助:
国家自然科学基金项目“新型5α-还原酶抑制剂干扰血-附睾屏障后附睾腔液蛋白的筛选鉴定研究”(81100463);上海市自然科学基金项目“基于雄激素调控附睾功能和基因表达探索淫羊藿苷干预度他雄胺所致附睾不育的机制研究”(17ZR1424300)

Progress in Establishment and Application of Laboratory Animal Models Related to Development of Male Infertility Drugs

Shuwu XIE()(), Ruling SHEN, Jinxing LIN, Chun FAN

Shanghai Laboratory Animal Research Center, Shanghai 201203, China

Received:2023-08-21 Revised:2023-10-14 Published:2023-10-25 Online:2023-11-01
Contact: XIE Shuwu (ORCID: 0000-0001-5753-6824), E-mail:xieshw@fudan.edu.cn

摘要/Abstract

摘要：

近年来男性不育发病率不断上升，急需开展雄性不育发病机制和相应药物研发，以应对我国人口出生率下降和老龄化等新问题。雄性不育动物模型的构建和应用是其中很重要的一环，它对于准确评价不育治疗药物的药效及作用机制等都具有重要作用。合适的不育动物模型不仅可以减少药物药效的重复评价，降低动物使用和新药研发成本，而且对于后续临床试验也具有重要的参考价值。雄性不育动物模型可以通过化学、物理、内分泌、环境雌激素、基因修饰和免疫等方法构建。本文主要介绍了现有的雄性不育药物研发相关实验动物模型，并对各模型应用现状进行了简要介绍，以期为雄性不育药物研发人员提供有益的参考。

关键词: 雄性不育, 药物研发, 实验动物模型

Abstract:

As the incidence of male infertility has been increasing during recent years, it is urgent to reveal the pathogenesis of male infertility, as well as to develop the new drugs for treatment of male infertility, in order to solve the declining birth rate and aging problems. The construction and application of male infertile animal models is critical for drug development, which plays an important role in accurately evaluating the efficacy and mechanism of infertility treatment. A suitable infertility model not only can reduce the repeated drug efficacy evaluations, reduce animal usage and the cost of new drug development, but also has important reference value for subsequent clinical trial research. Male infertility laboratory animal models can be constructed through chemical, physical, endocrine, environmental estrogen, gene modification, and immune methods. This article mainly introduces the existing male infertility animal models available for drug development, and briefly introduces the application progress of each model to provide reference for the male infertility drug researchers.

Key words: Male infertility, Drug development, Laboratory animal models

中图分类号:

R-339.2

谢淑武, 沈如凌, 林金杏, 范春. 雄性不育药物研发相关实验动物模型建立和应用进展[J]. 实验动物与比较医学, 2023, 43(5): 504-511.

Shuwu XIE, Ruling SHEN, Jinxing LIN, Chun FAN. Progress in Establishment and Application of Laboratory Animal Models Related to Development of Male Infertility Drugs[J]. Laboratory Animal and Comparative Medicine, 2023, 43(5): 504-511.

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雄性不育药物研发相关实验动物模型建立和应用进展

Progress in Establishment and Application of Laboratory Animal Models Related to Development of Male Infertility Drugs

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