先兆子痫动物模型的制备

doi:10.3969/j.issn.1674-5817.2016.06.013

摘要/Abstract

摘要： 先兆子痫(PE)是以高血压、蛋白尿、水肿为主要临床特征的妇产科疾病,并常伴有全身多个脏器损害, 是严重威胁母婴安全、导致孕、产妇及围生儿发病及死亡的重要原因,其病因及发病机制至今尚未完全明确。借助PE动物模型开展相关研究,是阐明该疾病的发病机制或药物疗效的重要手段。目前,该疾病的造模方法主要分为环境刺激法、化学药物干扰法、手术干预法、基因干预法四类。所选择的动物主要有大鼠、小鼠。此外,家兔、犬、猕猴、狒狒、羊等在手术干预法中也有应用。在PE发病机制的研究中,动物模型起着重要作用,本文对PE动物模型制备方法进行综述,并进一步介绍了各种方法制备的动物模型的评价标准及其特点。

关键词: 先兆子痫(PE), 动物模型, 制备, 综述

Abstract: Pre-eclampsia (PE) is a common obstetrical and gynecological disease with the hypertension, proteinuria and edema as the main clinical symptom, and accompanying with multiple organ damages. The disease is a serious threat to maternal and child safety and the leading cause of maternal and perinatal morbidity. However, the etiology and pathogenesis of PE is not clarified yet. Using animal models of PE to research human diseases is an important mean to clarify the pathogenesis of the disease or drug efficacy. There are four methods of PE animal modeling: environmental stimulation, chemical drug interference, surgical intervention and gene intervention. Rats and mice are mainly selected to prepare animal models of the PE. In addition, rabbits, dogs, rhesus monkeys, baboons and sheep are also commonly used for preparing the animal models by surgical intervention. In this paper, the preparation methods of PE animal models were reviewed, and the evaluation standards and characteristics of these animal models were introduced.

Key words: Pre-eclampsia(PE), Animal model, Preparation, Review

中图分类号:

R711Q95-33

李冬冬, 朱敏, 庞琴霞, 丁佩芳. 先兆子痫动物模型的制备[J]. 实验动物与比较医学, 2016, 36(6): 466-472.

LI Dong-dong, ZHU Min, PANG Qin-xia, Ding Pei-fang. Preparation of Pre-eclampsia Animal Model[J]. Laboratory Animal and Comparative Medicine, 2016, 36(6): 466-472.

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