基于VOSviewer的肌少症动物模型研究可视化分析

doi:10.12300/j.issn.1674-5817.2023.015

摘要/Abstract

摘要：

目的分析肌少症动物模型研究的现状、热点及发展趋势，为肌少症动物模型研究提供方向与基础资料。方法检索 Web of Science（WOS）核心合集数据库中1900-01-01至2022-12-31的肌少症动物模型研究英文文献，以及中国知网（CNKI）数据库中1915—2022年的肌少症动物模型研究中文文献。应用文献计量分析软件VOSviewer分析发文量、发文国家/地区、机构、作者、期刊及关键词，以揭示该领域研究的主要国家和机构以及热点和前沿方向。结果从WOS核心合集数据库共检索到肌少症动物模型相关文献2 819篇，第1篇文献发表于1995年；美国是肌少症动物模型研究最多的国家，发文量为1 105篇；发文机构最多的是美国佛罗里达大学，发文量为69篇；香港大学是我国发文量最多的机构，共发文20篇；美国学者Holly V R的发文量最多，发表50篇；肌少症动物模型研究刊文量最多的学术期刊是美国的FASEB Journal，刊文量为196篇。CNKI数据库共检索到文献423篇，中文发文量最多的作者是李柱一，共发文19篇。WOS检索文献的关键词共现聚类分析发现，肌少症动物模型研究的热点可概括为肌少症与代谢相关性研究，肌少症动物模型细胞学及再生医学研究，肌少症动物模型与骨、肌肉和神经研究，以及肌少症与运动治疗研究。CNKI数据库检索发现失神经性肌少症模型研究最为广泛，中药对肌少症的作用研究也多有报告。文献阅读发现肌少症动物模型主要包括自然衰老模型、遗传修饰模型、高脂饮食诱导模型、失用性肌少症模型、激素诱导模型及其他疾病复合性的肌少症模型。结论肌少症动物模型是近年来国内外研究的一个热点，文献计量分析在研究方向及热点、模式动物选择、动物模型制作、国内外交流与合作等方面可为肌少症动物模型研究提供基础。

关键词: 肌少症, 动物模型, 文献计量, 可视化分析

Abstract:

Objective Analyze the current situation, hotspots and development trends of sarcopenia animal model to provide research direction and basic information for sarcopenia animal model research. Methods English literature of research on animal models of sarcopenia was retrieved from the Web of Science core data (WOS) set from 1900-01-01 to 2022-12-31. Chinese literature related to animal models of sarcopenia was retrieved from CNKI database between 1915 and 2022. The bibliometric analysis software VOSviewer was used to explore the countries, orgonizations, authors, hotspots and frontier directions in these studies. Results A total of 2 819 articles on animal models of sarcopenia were retrieved from WOS core database. The first paper was published in 1995. The United States has the largest number of animal model studies of sarcopenia with 1 105 articles. The institution with the most published articles is the University of Florida in the United States, with 69 articles. The University of Hong Kong has the highest number of publications in China, with 20 articles. American author Van Remmen H, with 50 publications, is the author of the most articles. The journal with the largest number of articles published on animal models of sarcopenia is the American journal called FASEB Journal, with 196 articles. In total, 423 articles on animal models of sarcopenia were retrieved from the CNKI database. Author LI Zhuyi has published 19 articles, and is the author of the most articles in China. The keyword co-occurrence clustering analysis of WOS literature search found that the research focus on animal model of sarcopenia can be summarized as the correlation between sarcopenia and metabolism, cytology and regenerative medicine of sarcopenia animal models, the study of sarcopenia animal models in bone, muscle, nerve and exercise therapy. The retrieval results of CNKI database revealed that the most extensive research was about on the model of denervated sarcopenia, and researches on the effects of Chinese medicine on sarcopenia were also widely reported. Through reading the full articles or abstracts of the literature, the animal models of sacopenia mainly include natural aging model, genetic modification model, high-fat diet induction model, disuse model, hormone induction model and complex sarcopenia models of other diseases. Conclusion In recent years, the study on animal model of sarcopenia has become a hotspot at home and abroad.The bibliometric analysis provides a basis for the research of animal models of sarcopenia in terms of research direction, hotspots, model animal selection, animal model making, and domestic and international communication and cooperation.

Key words: Sarcopenia, Animal model, Bibliometrics, Visual analysis

中图分类号:

R-332

相磊, 景金珠, 梁震, 阎国强, 郭文峰, 张萌, 张威, 刘亚军. 基于VOSviewer的肌少症动物模型研究可视化分析[J]. 实验动物与比较医学, 2023, 43(4): 429-439.

Lei XIANG, Jinzhu JING, Zhen LIANG, Guoqiang YAN, Wenfeng GUO, Meng ZHANG, Wei ZHANG, Yajun LIU. A Visual Analysis on Animal Model of Sarcopenia Based on VOSviewer[J]. Laboratory Animal and Comparative Medicine, 2023, 43(4): 429-439.

图/表 9

图1 肌少症动物模型研究的发文量统计注：A，英文发文量统计（WOS核心合集数据库）；B，中文发文量统计（CNKI数据库）。

Figure 1 Statistics of the quantities of research articles on animal models of sarcopeniaNote：A， Statistics on the number of articles published in English（Web of Science core data）； B， Statistics on the number of articles published in Chinese（CNKI database）.

图2 肌少症动物模型研究的国家（或地区）和机构共现可视化图谱注：圆圈与标签组成一个单元，不同颜色的单元组成不同的簇。不同国家（或地区）和机构之间按不同颜色分类，节点的大小表示发文频次的多少，机构之间距离越近反映合作越密切。

Figure 2 Co-occurrence visualization map of institutions and countries/ regions for sarcopenia animal model researchNote： Circles and labels form a unit, and units of different colors form different clusters. The countries (or regions) and institutions are classified according to different colors, and the size of the nodes indicates the frequency of publishing articles. The closer the distance between the institutions, the closer the cooperation.

表1 不同国家和机构的肌少症动物模型研究发文量与引用统计（前10位）

Table 1 The number of articles and citations statistics of sarcopenia animal models in different countries and institutions (top 10)

排名 Sort	国家 Countries	发文量 Documents	引用频次 Citations	排名 Sort	机构 Organizations	发文量 Documents	引用频次 Citations
1	美国	1 105	45 206	1	美国佛罗里达大学	69	4 549
2	日本	369	6 570	2	美国克利夫兰诊所	49	931
3	中国（含港澳台）	278	3 677	3	美国妙佑医疗国际	46	958
4	意大利	211	9 291	4	法国农业科学研究院	45	1 889
5	法国	179	5 879	5	美国密歇根大学	45	2 280
6	韩国	177	2 107	6	英国利物浦大学	42	1 117
7	英国	170	5 506	7	日本东京大学	40	1 232
8	加拿大	127	4 111	8	美国威斯康星大学	40	2 582
9	德国	96	2 267	9	美国得克萨斯大学	37	2 067
10	西班牙	95	3 917	10	美国俄克拉何马医学院	36	688

图3 肌少症动物模型研究的作者共现可视化图谱注：A，英文文献发文作者共现；B，中文文献发文作者共现。圆圈和标签组成一个单元，不同颜色的单元组成不同的簇。作者之间按不同颜色分类，分别代表不同的研究团队，节点的大小表示作者出现的频率高低。作者间无相互关联性，图中均不呈现。

Figure 3 Co-occurrence map of the authors in the study of animal model of sarcopeniaNote： A， The co-occurrence of the authors in the English literature； B， The co-occurrence of the authors in Chinese literature. Circles and labels form a unit， and units of different colors form different clusters. The authors are classified according to different colors that represent different research teams. The size of the node indicates the frequency of the occurrence of the authors. There is no correlation between the authors， and these authors are not shown in the figure.

表2 中外作者在肌少症动物模型研究中的发文量统计（前10位）

Table 2 Statistics of the number of articles published by Chinese and foreign authors in the study of animal models of sarcopenia (top 10)

排名	Web of Science核心合集数据库（WOS）		CNKI数据库（CNKI）
Sort	作者 Authors	发文量 No. of published articles	作者 Authors	发文量 No. of published articles
1	Van remmen Holly	50	李柱一	19
2	Dasarathy Srinivasan	48	孙圣刚	15
3	Kumar Avinash	31	王云甫	15
4	Mcardle Anne	29	曹学兵	14
5	Leeuwenburgh Christiaan	28	文颖娟	10
6	Walrand Stephane	26	孟繁平	9
7	Davuluri Gangarao	25	杨俊超	8
8	Sieck Gary C	24	梅晓云	8
9	Vasilaki Aphrodite	24	何国厚	7
10	Brotto Marco	23	刘睿	7

图4 肌少症动物模型相关研究发表期刊及中英文文献中关键词共现聚类图谱注：A，发表期刊的共现分析；B，英文文献关键词共现；C，中文文献关键共现。圆圈和标签组成一个单元，不同颜色的单元组成不同的簇，不同颜色分别代表不同的杂志或研究方向，节点的大小表示杂志刊文的频次高低或关键词出现的频率高低。

Figure 4 Published journals and keywords co-occurrence cluster map in animal model study of sarcopenia in Chinese and English literatureNote：A, co-occurrence analysis of published journals; B, Co-occurrence of key words in English literature; B, Co-occurrence of key words in Chinese literature. Circles and labels form a unit, units of different colors form different clusters, different colors represent different magazines or different research directions, and the size of nodes indicates the frequency of magazine articles or keyword occurrence.

表3 肌少症动物模型研究期刊发表文献的共引用统计（前10位）

Table 3 Co-citation statistics of articles published in animal model research journals of sarcopenia（top 10）

排名 Sort	杂志名称 Journal	影响因子（2023） Impact factor	发文量/篇 Documents	共引用频次/次 Citations
1	FASEB Journal	4.8	196	3 020
2	Experimental Gerontology	3.9	111	3 906
3	Journal of Cachexia Sarcopenia and Muscle	8.9	107	1 963
4	Nutrients	5.9	67	1 140
5	Aging Cell	7.8	58	2 770
6	Aging-Us	5.2	52	1 486
7	International Journal of Molecular Sciences	5.6	50	356
8	Journals of Gerontology Series A-Biological Sciences and Medical	5.1	48	2 295
9	Journal of Applied Physiology	3.3	45	1 803
10	Frontiers in Physiology	4.0	44	652

表4 肌少症动物模型研究中的中英文关键词分析（前10位）

Table 4 English and Chinese keywords analysis in the study of animal model of sarcopenia (top 10)

排名 Sort	英文关键词 English keywords	共现频率 Co-occurrence frequency	排名 Sort	中文关键词 Chinese keywords	共现频率 Co-occurrence frequency
1	sarcopenia	961	1	重症肌无力	153
2	aging	590	2	肌萎缩	124
3	skeletal muscle/muscle	529	3	大鼠	41
4	muscle atrophy	239	4	失神经	23
5	mitochondria	142	5	乙酰胆碱受体	21
6	oxidative stress	123	6	骨骼肌	17
7	exercise	93	7	小鼠	16
8	inflammation	75	8	失重模拟	14
9	autophagy	70	9	肌少症	13
10	cachexia	68	10	乙酰胆碱受体抗体	11

表5 英文和中文文献中肌少症动物模型研究关键词聚类分析

Table 5 Cluster analysis of key words in animal model of sarcopenia in English and Chinese literature

聚类 Clusters	英文文献关键词 Keywords in English literature	中文文献关键词 Keywords in Chinese literature
1	body composition, cachexia, cancer cachexia, chronic kidney disease, inflammation, insulin resistance, metabolism, muscle atrophy, muscle regeneration, muscle wasting, myogenesis, myostatin, obesity, sarcopenia, sarcopenia obesity, skeletal muscle atrophy	动物、失重模拟、小鼠、模拟失重、比目鱼肌、电针、肌、骨骼
2	aging, atrophy, hypertrophy, motor, protein synthesis, regeneration, satellite cells, skeletal muscle	乙酰胆碱受体、兔、动物模型、实验性自身免疫性重症肌无力、糖尿病、肌少症
3	aging, apoptosis, autophagy, mice, mitochondria, mitophagy, oxidative stress, reactive oxygen species	多发性硬化、帕金森病大鼠、肌阵挛、阿尔茨海默病
4	bone, muscle, osteoporosis, senescence, vitamin D	中枢神经系统、乙酰胆碱受体抗体、受体、抗体、胆碱能
5	Exercise, frailty, nutrition	Bcl-2、大鼠、细胞凋亡、肌损伤、腓肠肌
6	denervation, neuromuscular junction	MAFBX、去神经支配、肌纤维、肌萎缩、骨骼肌
7	muscle mass	咬肌、线粒体、葛根复方、超微结构
8		失神经、胫前肌、补阳还五汤、黄芪
9		免疫性、细胞因子、重症肌无力

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