TX 小鼠研究进展

doi:10.3969/j.issn.1674-5817.2016.06.014

摘要/Abstract

摘要： TX 小鼠(toxic milk mouse)是由DL近交系小鼠繁殖到第68 代所产生的自然突变品系。主要表现为低色素化、生长迟缓、震颤和运动功能障碍等,其与Wilson 病的共同点包括: 遗传方式属于常染色体隐性遗传、成年小鼠体内铜大量沉积使血清铜和血清铜蓝蛋白水平降低等特点。文章从TX 小鼠的病理生理学、致病机理、病理治疗学等多个方面综述了TX小鼠的研究现状。

关键词: TX 小鼠, 铜离子积累, ATP7B 蛋白

Abstract: Toxic milk mouse is mutant a strain that produced by DL mice at F68. The main pathological shows are low pigmentation, growth retardation, tremor and movement disturbance. The common ground with Wilson disease are autosomal recessive inheritance, and large quantities of copper deposit in adult mouse that lead the levels of serum copper and serum ceruloplasmin protein declined. This paper reviews the researches on Toxic milk from several aspects, including pathophysiology, disease mechanism, diagnostics and therapy.

Key words: Toxic milk mouse, Accumulation of copper, Protein ATP7B

中图分类号:

Q95-33

张薇,唐彬,黎福荣. TX 小鼠研究进展[J]. 实验动物与比较医学, 2016, 36(6): 473-478. DOI: 10.3969/j.issn.1674-5817.2016.06.014.

ZHANG Wei,TANG Bin,LI Fu-rong. Research Progress on Toxic Milk Mouse[J]. Laboratory Animal and Comparative Medicine, 2016, 36(6): 473-478. DOI: 10.3969/j.issn.1674-5817.2016.06.014.

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