自噬与帕金森疾病及相关性模型的研究进展

doi:10.3969/j.issn.1674-5817.2015.04.020

摘要/Abstract

摘要： 帕金森病(Parkinson抯 disease, PD)是一种常见的神经退行性疾病,严重影响老年人生活质量,目前其发病机制尚不明确,环境和遗传等因素均与其发病机制密切相关。越来越多的研究表明,线粒体功能异常和自噬损伤可能是导致PD发病的关键分子机制之一,因此,利用细胞模型及PD动物模型研究自噬对PD发病机制的作用具有重要意义。本文就线粒体自噬与帕金森疾病相关性的研究进展做简要的介绍。

关键词: 自噬, 线粒体, 帕金森病(PD), 模型

Abstract: Parkinson disease (PD) is a common neurodegeneration disease, it has seriously affect on quality of life in elder. At present the pathogenesis of PD is unclear, environmental and genetic factors are closely related with it. An increasing number of evidences suggest that mitochondrial dysfunction and autophagy damage may be one of the key molecular mechanisms leading to the onset of PD, thus it would be significant to study the role of autophagy in the pathogenesis of PD by using cellular models and PD animal models. The paper briefly review the research progress of mitochondrial autophagy correlation with Parkinson's disease.

Key words: Autophagy, Mitochondria, Parkinson disease(PD), Model

中图分类号:

Q95-33

李媛, 张梅英. 自噬与帕金森疾病及相关性模型的研究进展[J]. 实验动物与比较医学, 2015, 35(4): 335-340.

LI Yuan, ZHANG Mei-ying. Research Progress on Autophagy with Parkinson Disease and Related Models[J]. Laboratory Animal and Comparative Medicine, 2015, 35(4): 335-340.

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