图1 碘酸钠注射后雌雄鼠体质量变化曲线图注：模型组一次性腹腔注射质量浓度为6 mg/mL碘酸钠溶液10 mL/kg；阴性对照组以相同容积和频次腹腔注射生理盐水注射液。各时间点两组大鼠数量分别为单性别16、16、14、12、12、12、12、10、10、4、4、2、2、2只；与阴性对照组间比较，?P＜0.05。

Figure 1 Body weight curve of male and female rats after sodium iodate injectionNote：The model group was intraperitoneally injected with 6 mg/mL sodium iodate solution once at the dose of 10 mL/kg；the negative control group was intraperitoneally injected with normal saline at the same volume and frequency. The number of rats in the two groups at each time point was 16， 16， 14， 12，12， 12， 12， 10， 10， 4， 4， 2， 2， 2 respectively for single sex. Compared with the negative control group， ?P＜0.05.

图2 碘酸钠注射后雌雄鼠血清生化指标变化注：模型组一次性腹腔注射质量浓度为6 mg/mL碘酸钠溶液10 mL/kg；阴性对照组以相同容积和频次腹腔注射生理盐水注射液。各时间点两组大鼠数量分别为单性别2、2、2、6、2、2只；与阴性对照组比较，?P＜0.05。

Figure 2 Changes of serum biochemical indexes of male and female rats after sodium iodate injectionNote： The model group was intraperitoneally injected with 6 mg/mL sodium iodate solution once at the dose of 10 mL/kg； the negative control group was intraperitoneally injected with normal saline at the same volume and frequency. The number of rats in the two groups at each time point was 2， 2， 2， 6， 2， 2 respectively for single sex. Compared with the negative control group， ?P＜0.05.

图3 碘酸钠注射后雌雄鼠血常规指标变化注：模型组一次性腹腔注射质量浓度为6 mg/mL碘酸钠溶液10 mL/kg；阴性对照组以相同容积和频次腹腔注射生理盐水注射液。各时间点两组大鼠数量分别为单性别2、2、2、6、2、2只；与阴性对照组间比较，??P＜0.01。

Figure 3 Changes of blood routine indexes of male and female rats after sodium iodate injectionNote：The model group was intraperitoneally injected with 6 mg/mL sodium iodate solution once at the dose of 10 mL/kg；the negative control group was intraperitoneally injected with normal saline at the same volume and frequency. The number of rats in the two groups at each time point was 2， 2， 2， 6， 2， 2 respectively for single sex. Compared with the negative control group， ??P＜0.01.

图4 碘酸钠注射后雌雄鼠各脏器质量及系数变化图注：模型组一次性腹腔注射质量浓度为6 mg/mL碘酸钠溶液10 mL/kg；阴性对照组以相同容积和频次腹腔注射生理盐水注射液。各时间点两组大鼠数量分别为单性别2、2、2、6、2、2只。

Figure 4 Changes of organ weight and coefficient of male and female rats after sodium iodate injectionNote：The model group was intraperitoneally injected with 6 mg/mL sodium iodate solution once at the dose of 10 mL/kg；the negative control group was intraperitoneally injected with normal saline at the same volume and frequency. The number of rats in the two groups at each time point was 2， 2， 2， 6， 2， 2 respectively for single sex.

图5 碘酸钠注射后不同时间点的大鼠眼视网膜病变情况（HE染色， ×400）注：模型组一次性腹腔注射质量浓度为6 mg/mL碘酸钠溶液10 mL/kg；阴性对照组以相同容积和频次腹腔注射生理盐水注射液。各时间点两组大鼠数量分别为单性别2、2、2、6、2、2只。a示模型组注射后第3天视网膜呈波浪样改变；b示模型组注射后第7天视网膜呈异常心电图样改变，各层排列紊乱；图c～f分别示模型组注射后第21、28、41、62天视网膜呈异常心电图样改变，各层排列紊乱、外核层局灶变薄；g示阴性对照组视网膜正常；h-i为两组大鼠的视网膜病变发生率及HE评分比较（病变1为视网膜呈波浪样改变，病变2为视网膜呈心电图样改变）与阴性对照组比较，??P<0.01。图中比例尺大小均为50 μm。

Figure 5 Retinopathy in rats at different time points after sodium iodate injection （HE staining， ×400）Note：The model group was intraperitoneally injected with 6 mg/mL sodium iodate solution once at the dose of 10 mL/kg； the negative control group was intraperitoneally injected with normal saline at the same volume and frequency. The number of rats in the two groups at each time point was 2， 2， 2， 6， 2， 2 respectively for single sex. a shows the retina of the model group appeared wave-like changes on the 3rd day after injection； b shows the retina of the model group appeared abnormal electrocardiogram （ECG）-like changes on the 7th day after injection， and the arrangement of each layer was disordered； c-f show the retina of the model group appeared abnormal ECG-like changes on the 21st， 28th， 41st and 62nd days after injection， with disordered arrangement of each layer and focal thinning of the outer nuclear layer. g shows normal retina in negative control group； h-i show the comparison of the incidence of retinopathy and HE score between the two groups （Lesion 1 shows wave-like changes in the retina， lesion 2 shows ECG-like changes in the retina）. ??P<0.01， vs the negative control group. The scale size in the figure are 50 μm.

图6 碘酸钠注射后不同时间点的大鼠眼视网膜TUNEL染色情况（×400）注：模型组一次性腹腔注射质量浓度为6 mg/mL碘酸钠溶液10 mL/kg；阴性对照组以相同容积和频次腹腔注射生理盐水注射液。各时间点两组大鼠数量分别为单性别2、2、2、6、2、2只。a～f分别示模型组注射后第3、7、21、28、41、62天视网膜外核层细胞TUNEL染色阳性（箭头所示为TUNEL染色阳性细胞）；g示阴性对照组视网膜TUNEL染色阴性；h为两组大鼠的视网膜外核层TUNEL染色阳性细胞数比较，与阴性对照组比较，??P<0.01。图中比例尺大小均为50 μm。

Figure 6 TUNEL staining of rat retina at different time points after sodium iodate injection （×400 ）Note：The model group was intraperitoneally injected with 6 mg/mL sodium iodate solution once at the dose of 10 mL/kg；the negative control group was intraperitoneally injected with normal saline at the same volume and frequency. The number of rats in the two groups at each time point was 2， 2， 2， 6， 2， 2 respectively for single sex. a-f show that TUNEL staining was positive in the outer nuclear layer of the retina on the 3rd， 7th， 21st， 28th， 41st and 62nd days after injection in the model group （the arrows show TUNEL staining positive cells）； g shows that the TUNEL staining of the retina in the negative control group was negative； h shows the comparison of the number of TUNEL staining positive cells in the outer nuclear layer of the two groups of rats. ??P<0.01， vs the negative control group. The scale size in the figure are 50 μm.