›› 2008, Vol. 28 ›› Issue (6): 411-415.

• 论文 • 上一篇    下一篇

脊髓损伤动物模型的构建与应用

  

  1. 中国医科大学实验动物学部,沈阳 110001
  • 收稿日期:2008-09-05 出版日期:2008-06-30 发布日期:2008-06-30

The Construction, and Application of Animal Models for Spinal Cord Injury

  1. The Department of Laboratory Animal Science of China Medical University, Shen Yang 110001,China
  • Received:2008-09-05 Online:2008-06-30 Published:2008-06-30

摘要: 由于人类疾病发生发展复杂,而许多医学研究并不允许在人体上实验,因此可复制人类疾病的动物模型在医学研究中起着日趋重要的作用。脊髓损伤机制和再生修复治疗是目前神经科学研究中的难题,脊髓损伤动物模型的建立和发展为突破这一难题起到了非常重要的作用。本文旨在介绍建立脊髓损伤动物模型的动物选择,以及各种脊髓损伤模型的建立方法、特点及应用。

关键词: 动物模型, 脊髓损伤

Abstract: For the reasons that the genesis and development of human being’s diseases are complicated, and many medical researches are not permitted to be applied on human bodies, the kinds of animal models, which are replicable for human diseases, are playing a more and more indispensable role in medical research. The mechanism of spinal cord injury and regeneration is a difficult problem in current neuroscience research. However, the construction and development of the animal model for spinal cord injury provides a powerful support for breakthrough. This review aims at introduce how to choose animals, the means of constructing each kind of spinal cord injury model, the characteristic and the application of each kind of spinal cord injury model.

Key words: Animal model, Spinal cord injury