斑马鱼糖尿病模型的构建及应用进展

doi:10.3969/j.issn.1674-5817.2020.06.016

摘要/Abstract

摘要： 糖尿病是一组代谢紊乱性疾病,其发病机制至今尚未完全阐明。糖尿病主要分为1型糖尿病、2型糖尿病和妊娠糖尿病。常用的糖尿病模型动物主要有小鼠、大鼠、兔、小型猪和猕猴等。另外,斑马鱼（Danio rerio）作为一种模式生物,在很多领域已被用于构建人类疾病模型,包括1型糖尿病和2型糖尿病研究中斑马鱼模型也取得了一定的应用进展。本文总结了现有的斑马鱼糖尿病模型构建方法以及应用进展,以期为今后糖尿病斑马鱼模型研究及应用提供参考。

关键词: 糖尿病, 斑马鱼, 动物模型, 1型糖尿病, 2型糖尿病

Abstract: Diabetes mellitus is a group of metabolic disorders, and its pathogenesis has not been fully elucidated. Diabetes mainly includes type 1 diabetes, type 2 diabetes and gestational diabetes. Many animals such as mice, rats, rabbits, mini-pigs and macaques are commonly used as diabetes models. As a model organism, zebrafish (Danio rerio) has been widely used to simulate human disease in many fields, including type 1 and type 2 diabetes mellitus. By searching a large amount of literature, this article summarized the current construction methods of zebrafish models of diabetes and its application progress in order to provide references for its future research and application.

Key words: Diabetes, Zebrafish, Animal model, Type 1 diabetes mellitus, Type 2 diabetes mellitus

中图分类号:

江霞, 钱豪杰, 魏迅, 郑羽旋, 周正宇. 斑马鱼糖尿病模型的构建及应用进展[J]. 实验动物与比较医学, 2020, 40(6): 547-552.

JIANG Xia, QIAN Haojie, WEI Xun, ZHENG Yuxuan, ZHOU Zhengyu. Research Progress in Construction and Application of Diabetes Model in Zebrafish[J]. Laboratory Animal and Comparative Medicine, 2020, 40(6): 547-552.

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