实验动物与比较医学 ›› 2012, Vol. 32 ›› Issue (6): 489-492.DOI: 10.3969/j.issn.1674-5817.2012.06.007

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骨-腱结点动物模型的建立及MRI动态观察

梁佩红, 李爱国, 何敏聪, 钟敏之, 陈松, 梁治平, 杨小红, 王文   

  1. 暨南大学医学院附属广州市红十字会医院 广州市创伤外科研究所, 广州 510220
  • 收稿日期:2012-06-06 出版日期:2012-12-25 发布日期:2012-12-25
  • 作者简介:梁佩红(1965-),女,副主任技师,研究方向:创伤外科,E-mail:lph2009@126.com
  • 基金资助:
    国家自然科学基金项目(30973067)、广州市医药卫生科技项目(201102A213159)、广州市卫生局重点项目(201102A212003)

Establishing a New bone- tendon Junction Injure Model in Rat Facilitating MRI Detection

LIANG Pei-hong, LI Ai-guo, HE Ming-chong, ZHONG Ming-zhi, CHEN Shong, LIANG Zhi-ping, YANG Xiao-hong, WANG Wen, CHEN Hong-hui   

  1. The Fourth Affiliated Hospital of Jinan University, Institute of Traum atology, Guangzhou 510220, China
  • Received:2012-06-06 Online:2012-12-25 Published:2012-12-25

摘要: 目的 建立骨–肌腱结点愈合过程的动物模型并进行MRI观察。方法 用12只新西兰大白兔分别行兔髌骨部分切除后,再行髌腱结合术,于术后2周、4周、8周、12周进行大体和MRI检查。结果 大体和MRI检查动态显示术后2、4、8、12周骨-肌腱结合部组织愈合过程,该过程以松质骨再生和骨–肌腱愈合接点纤维软骨带的再生为特征,随着时间的增长逐渐恢复。结论 经改良的动物模型不影响骨-肌腱结点愈合,有利于MRI的正确观察。

关键词: 骨-肌腱结合部, 愈合, 动物模型, MRI

Abstract: Objective To establish a new bone-tendon junction injury animal models for better observation with MRI. Methods The patella of 12 mature New Zealand white rabbits were partially resected and then the tendon were sutured to bone.General examination and MRI were done after 2, 4, 8 and 12 weeks. Results The general examination and MRI results showed the healing process of bone-tendon junction dynamically in 2, 4, 8, 12 weeks after operation. The process was featured as cancellous bone regeneration and bone- tendon healing contact fibrocartilage zone regeneration, which was restored gradually as time pasted. Conclusions The modified animal models do not affect bone-tendon junction healing and is better for MRI observation correctly.

Key words: Bone-tendon junction, Animal model, MRI

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