应激性心肌病动物模型的研究进展

doi:10.12300/j.issn.1674-5817.2022.102

实验动物与比较医学 ›› 2023, Vol. 43 ›› Issue (2): 173-179.DOI: 10.12300/j.issn.1674-5817.2022.102

应激性心肌病动物模型的研究进展

吴昊晟¹(), 苏航¹, 朱超¹, 王文慧¹, 吴生兵²^,³, 崔帅²^,⁴, 周美启⁴^,⁵()()

^1.安徽中医药大学研究生院, 合肥 230012
^2.安徽中医药大学针灸经络研究所, 合肥 230038
^3.安徽中医药大学针灸学院, 合肥 230012
^4.新安医学教育部重点实验室, 合肥 230012
^5.安徽省中医药科学院亳州中医药研究所, 亳州 236800

收稿日期:2022-07-06 修回日期:2022-09-21 出版日期:2023-04-25 发布日期:2023-05-16
通讯作者: 周美启（1963—），男，博士，教授，博士研究生导师，研究方向：经脉脏腑相关研究。E-mail：meiqizhou@163.com。ORCID： 0000-0002-8798-7121
作者简介:吴昊晟（1997—），男，硕士研究生，研究方向：经脉脏腑相关研究。E-mail：811985763@qq.com
基金资助:
国家重点研发计划“基于心/肺经的经脉关键问题创新研究”(2018YFC1704600);安徽省中医药领军人才建设项目(ZYYLJRC201911)

Research Progress of Animal Models of Stress Cardiomyopathy

Haosheng WU¹(), Hang SU¹, Chao ZHU¹, Wenhui WANG¹, Shengbing WU²^,³, Shuai CUI²^,⁴, Meiqi ZHOU⁴^,⁵()()

^1.Graduate School of Anhui University of Traditional Chinese Medicine, Hefei 230012, China
^2.Institute of Acupuncture and Meridians, Anhui University of Traditional Chinese Medicine, Hefei 230038, China
^3.School of Acupuncture and Moxibustion, Anhui University of Traditional Chinese Medicine, Hefei 230012, China
^4.Xin 'an Key Laboratory of Medical Science, Ministry of Education, Hefei 230012, China
^5.Bozhou Institute of Traditional Chinese Medicine, Anhui Academy of Traditional Chinese Medicine, Bozhou 236800, China

Received:2022-07-06 Revised:2022-09-21 Published:2023-04-25 Online:2023-05-16
Contact: ZHOU Meiqi (ORCID: 0000-0002-8798-7121), E-mail: meiqizhou@163.com

摘要/Abstract

摘要：

应激性心肌病（stress cardiomyopathy，SC）是一种由强烈精神刺激或躯体应激所致的急性心肌病。目前，在SC的急性或慢性阶段，能够有效降低死亡率、改善预后或预防复发的干预措施极少。因此，通过建立一种可靠、有效的SC动物模型来研究SC的发病机制及其防治方法，尤为重要。本文梳理了国内外现有SC模型的制备方法和评价指标，并展开综述，即论述了儿茶酚胺类激素注射法、束缚法、束缚联合电击法、束缚联合脱水法、迷走神经电刺激等造模方法的操作细节，以及利用旷场实验、心超、心电图、ELISA等方法对相关指标进行评价，以期为研究SC时的模型选择和建立提供有益参考。

关键词: 应激性心肌病, 动物模型, 造模方法, 评价指标

Abstract:

Stress cardiomyopathy (SC) is an acute cardiomyopathy caused by intense mental stimulation or physical stress. Currently, few interventions are effective in reducing mortality, improving prognosis, or preventing recurrence in acute or chronic stages of SC. Therefore, it is particularly important to establish a reliable and effective SC animal model to study the pathogenesis and prevention of SC. In this paper, the preparation methods and evaluation indexes of SC models at home and abroad were reviewed, including the operation details of catecholamine hormone injection method, binding method, binding combined with electroshock method, binding combined with dehydration method, vagus nerve electrical stimulation and other modeling methods, as well as evaluation indexes such as open field test, cardiac ultrasound, electrocardiogram and ELISA, striving to provide useful reference for model selection and establishment of SC research.

Key words: Stress cardiomyopathy, Animal model, Modeling method, Evaluation index

中图分类号:

R-332

吴昊晟, 苏航, 朱超, 王文慧, 吴生兵, 崔帅, 周美启. 应激性心肌病动物模型的研究进展[J]. 实验动物与比较医学, 2023, 43(2): 173-179.

Haosheng WU, Hang SU, Chao ZHU, Wenhui WANG, Shengbing WU, Shuai CUI, Meiqi ZHOU. Research Progress of Animal Models of Stress Cardiomyopathy[J]. Laboratory Animal and Comparative Medicine, 2023, 43(2): 173-179.

图/表 3

参考文献 43

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动物 Animal	品种或品系 Stock or strain	性别 Sex	年龄或体质量 Age/weight	药物 Drug	剂量 Dose	给药方案 Dosage regimen	参考文献 Reference
大鼠 Rat	SD	雄	250～300 g	ISO	50 mg/kg	单次腹腔注射	[9]
	SD	雌	2～4月龄，241±55 g	ISO	100 mg/kg	单次腹腔注射	[13]
	SD	雄	220～250 g，8周龄	ISO	100 mg/kg	不同部位多点皮下注射，持续3周	[14]
	SD	雌	300～350 g	NE	2～4 mg/kg	单次腹腔注射	[12]
	SD	雌	300～350 g	NE	4 mg/kg	单次腹腔注射	[15]
小鼠Mice	C57BL/6J	雄/雌	8～16周龄	ISO	200 mg/kg	单次腹腔注射	[16]
	C57BL/6J	/	16周	ISO	400 mg/kg	单次腹腔注射	[17]
	C57BL/6J	雄性	7周龄，20～25 g	ISO	50 mg/kg	腹腔注射3周	[18]
	129/Sv	/	8周	ISO	25 mg/kg	连续皮下注射5 d	[19]
	C57BL/ 6J	雄/雌	8周	ISO	30 mg/kg	皮下埋置微渗透泵，连续21 d释放ISO	[20]

动物 Animal	品种或品系 Stock or strain	性别 Sex	年龄或体质量 Age/weight	药物 Drug	剂量 Dose	给药方案 Dosage regimen	参考文献 Reference
大鼠 Rat	SD	雄	250～300 g	ISO	50 mg/kg	单次腹腔注射	[9]
	SD	雌	2～4月龄，241±55 g	ISO	100 mg/kg	单次腹腔注射	[13]
	SD	雄	220～250 g，8周龄	ISO	100 mg/kg	不同部位多点皮下注射，持续3周	[14]
	SD	雌	300～350 g	NE	2～4 mg/kg	单次腹腔注射	[12]
	SD	雌	300～350 g	NE	4 mg/kg	单次腹腔注射	[15]
小鼠Mice	C57BL/6J	雄/雌	8～16周龄	ISO	200 mg/kg	单次腹腔注射	[16]
	C57BL/6J	/	16周	ISO	400 mg/kg	单次腹腔注射	[17]
	C57BL/6J	雄性	7周龄，20～25 g	ISO	50 mg/kg	腹腔注射3周	[18]
	129/Sv	/	8周	ISO	25 mg/kg	连续皮下注射5 d	[19]
	C57BL/ 6J	雄/雌	8周	ISO	30 mg/kg	皮下埋置微渗透泵，连续21 d释放ISO	[20]

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应激性心肌病动物模型的研究进展

Research Progress of Animal Models of Stress Cardiomyopathy

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