胰腺星状细胞与胰腺疾病模型研究进展

doi:10.12300/j.issn.1674-5817.2021.088

摘要/Abstract

摘要：

常见的胰腺疾病类型有胰腺炎、糖尿病和胰腺癌。临床研究显示，在人体内胰腺星状细胞（pancreatic stellate cells，PSCs）可以从纤维化、氧化应激和炎性反应等方面影响胰腺病变，导致胰腺疾病的发生。本文综述了不同胰腺疾病的造模方法，以及PSCs对胰腺疾病发生发展的影响及其应用前景，以期为研究和治疗胰腺疾病提供新思路。

关键词: 动物模型, 胰腺星状细胞, 胰腺疾病

Abstract:

Common types of pancreatic diseases are pancreatitis, diabetes and pancreatic cancer. Clinical studies have found that pancreatic stellate cells (PSCs) in patients with pancreatic diseases, contributes to fibrosis, oxidative stress and inflammation, and lead to pancreatic diseases. This article reviewed the modeling methods of different pancreatic diseases, and the influence and application prospects of PSCs in pancreatic diseases, providing a new idea for the research and treatment of pancreatic diseases.

Key words: Animal model, Pancreatic stellate cells, Pancreatic disease

中图分类号:

Q95-33

魏迅, 江霞, 郑羽旋, 张乐文, 周正宇. 胰腺星状细胞与胰腺疾病模型研究进展[J]. 实验动物与比较医学, 2022, 42(2): 146-151.

Xun WEI, Xia JIANG, Yuxuan ZHENG, Lewen ZHANG, Zhengyu ZHOU. Progress of Pancreatic Stellate Cells in Research of Pancreatic Disease Model[J]. Laboratory Animal and Comparative Medicine, 2022, 42(2): 146-151.

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