膀胱出口部分梗阻动物模型的研究进展

doi:10.3969/j.issn.1674-5817.2018.06.012

实验动物与比较医学 ›› 2018, Vol. 38 ›› Issue (6): 463-467.DOI: 10.3969/j.issn.1674-5817.2018.06.012

膀胱出口部分梗阻动物模型的研究进展

陈林^1,2, 杨亚飞², 杨进¹, 何平林^1,2, 王凯^1,2, 王云汉¹, 汪自力¹

1.成都大学附属医院泌尿外科,成都 610081;
2.遵义医学院,遵义 563000

收稿日期:2018-07-04 出版日期:2018-12-25 发布日期:2021-03-01
作者简介:陈林(1986-),男,博士,硕士研究生导师。E-mail:clin360@gmail.com
基金资助:
国家自然科学基金项目(81500577);四川省科技厅资助项目(2017JY0098);成都市科技局项目(2015-HM01-00580-SF);成都市卫计委资助项目(2015123)

Research Progress on Animal Model of Partial Bladder Outlet Obstruction

CHEN Lin^1,2, YANG Ya-fei², YANG Jin¹, HE Pin-lin¹, WANG Kai¹, WANG Yun-han¹, WANG Zi-li¹

1. Department of Urology,Affiliated Hospital of Chengdu University,Chengdu 610081,China;
2. Zunyi Medical University,Zunyi 563000,ChinaLin Chen and Yafei Yang contributed equally to this work and should be considered as co-first authors

Received:2018-07-04 Online:2018-12-25 Published:2021-03-01

摘要/Abstract

摘要： 构建理想的膀胱出口部分梗阻(pBOO)动物模型是研究膀胱梗阻性疾病发病机制和开展药物治疗研究的关键。本文就pBOO动物模型的诱导方式选择(包括经耻骨上膀胱颈结扎法、尿道外口缝扎法、尿道外口皮下注射透明质酸等),及诱导pBOO动物模型的特点及局限性进行综述。

关键词: 膀胱出口部分梗阻(pBOO), 动物模型, 下尿路症状, 尿动力学

Abstract: Constructing an ideal animal model of bladder outlet partial obstruction (pBOO) is the key to study the pathogenesis of bladder obstructive diseases and conduct drug therapy research. In this article, we summarized the animal model induction methods, including the characteristics and limitations of animal models induced by suprapubic bladder neck ligation, extraurethral splenic suture, and subcutaneous hyaluronate injection outside the urethra, and the characteristics and disadvantages of induced pBOO model.

Key words: Partial bladder outlet obstruction (pBOO), Animal model, Lower urinary tract symptoms, Urodynamics

中图分类号:

Q95-33

陈林, 杨亚飞, 杨进, 何平林, 王凯, 王云汉, 汪自力. 膀胱出口部分梗阻动物模型的研究进展[J]. 实验动物与比较医学, 2018, 38(6): 463-467.

CHEN Lin, YANG Ya-fei, YANG Jin, HE Pin-lin, WANG Kai, WANG Yun-han, WANG Zi-li. Research Progress on Animal Model of Partial Bladder Outlet Obstruction[J]. Laboratory Animal and Comparative Medicine, 2018, 38(6): 463-467.

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膀胱出口部分梗阻动物模型的研究进展

Research Progress on Animal Model of Partial Bladder Outlet Obstruction

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