白内障动物模型的研究进展

doi:10.3969/j.issn.1674-5817.2018.01.017

实验动物与比较医学 ›› 2018, Vol. 38 ›› Issue (1): 78-82.DOI: 10.3969/j.issn.1674-5817.2018.01.017

• 综述 • 上一篇

白内障动物模型的研究进展

贾杰, 代解杰

中国医学科学院/北京协和医学院医学生物学研究所树鼩种质资源中心、云南省重大传染病疫苗研发重点实验室、云南省眼科疾病防治研究重点实验室、中国医学科学院医学生物学研究所实验树鼩标准化与应用研究省创新团队,昆明 650118

收稿日期:2017-07-28 出版日期:2018-02-25 发布日期:2021-03-01
作者简介:贾杰(1989-),男,在读博士,专业:病原生物学。E-mail:jiaiest@163.com
基金资助:
云南省科技人才和平台计划项目(2017HC019),重点实验室运行补助专项(2017DG008)

Research Progress in Animal Model of Cataract

JIA Jie, DAI Jie-jie

Center of Tree Shrew Germplasm Resources,Institute of Medical Biology,the Chinese Academy of Medical Science and Peking Union Medical College; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases; The Key Laboratory of Yunnan Province for Ophthalmic Research and Disease Control; Yunnan Innovation Team of Standardization and Application Research in Tree Shrew,Kunming 6500118,China

Received:2017-07-28 Online:2018-02-25 Published:2021-03-01

摘要/Abstract

摘要： 本文综述了近20年来国内外有关先天性、创伤性、人工诱导性和细胞水平白内障动物模型的建立方法、特点及相关机制研究,总结了各类型白内障动物模型构建的评价指标,提出了建立晶状体永生化细胞系,研究白内障发病过程晶状体细胞中基因表达水平的变化,以及建立与人类较相似的白内障树鼩模型的研究设想。

关键词: 白内障, 动物模型, 实验动物

Abstract: This paper summarized the method for establishing animal models of congenital,traumatic,artificially induced and cellular-level cataract that have been studied at domestic and abroad in nearly resent 20 years.The characteristics,evaluation criteria and related mechanisms of each model were also described.The paper also proposesed a method for studying the expression of gene in lens cells that in different state of cataract by established immortalized lens cell lines,and an assumption that setting up tree shrew model for cataract that are similar to human cataract.

Key words: Cataracts, Animal models, Laboratory animal

中图分类号:

Q95-33

贾杰, 代解杰. 白内障动物模型的研究进展[J]. 实验动物与比较医学, 2018, 38(1): 78-82.

JIA Jie, DAI Jie-jie. Research Progress in Animal Model of Cataract[J]. Laboratory Animal and Comparative Medicine, 2018, 38(1): 78-82.

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白内障动物模型的研究进展

Research Progress in Animal Model of Cataract

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