去氧乙烯基环己烯致雌鼠卵巢功能衰竭的动物模型研究进展

doi:10.3969/j.issn.1674-5817.2016.05.018

摘要/Abstract

摘要： 卵巢功能早衰(premature ovarian failure, POF)是一种以卵巢功能提前衰退为主要特征的生殖系统疾病。POF发病率虽高,但早期发现并诊断为POF的患者甚少,限制了对疾病的研究,因此建立与人类相似的生殖内分泌和组织学变化的POF模型对于POF发病机制的研究和进一步的治疗具有很大价值。实验中可以通过多种方法成功制备POF动物模型。本文主要从去氧乙烯基环己烯(4-vinylcyclohexene diepoxide,VCD)注射浓度的大小,注射时间的长短,利用不同日龄的雌鼠,不同物种,及与卵泡的募集、生长、发育和凋亡密切相关的众多调控因子等方面综述VCD诱导的卵巢功能衰竭模型的研究进展。

关键词: 去氧乙烯基环己烯(VCD), 卵巢功能早衰(POF), 研究进展, 动物模型

Abstract: Premature ovarian failure(POF) is a reproductive system disease as the main characteristics of ovarian function decline in advance.Although the high morbidity, there are few patients found and diagnosed early,which limits the study of the disease. Accordingly establishing the POF animal model which is similar to anthropic reproductive endocrinology and histological changes is of great value to POF pathogenesis reseach and further treatment.In experiments, POF model can be prepared by many methods, but current animal models of POF fail to adequately replicate this particular stage in female life.The article states the research progress of POF model induced by 4-vinylcyclohexene diepoxide (VCD) mainly on the diverse injection concentration, different injection time, disparate day age, distinct species and a large amount of regulatory factors which closely participated in follicular recruitment, growth and apoptosis.

Key words: 4-vinylcyclohexene diepoxide (VCD), Premature ovarian failure (POF), Research progress, Animal model

中图分类号:

Q95-33

耿利华, 谈勇. 去氧乙烯基环己烯致雌鼠卵巢功能衰竭的动物模型研究进展[J]. 实验动物与比较医学, 2016, 36(5): 404-408.

GENG Li-hua, TAN Yong. Research Progress on Premature Ovarian Failure Animal Model induced by Vinylcyclohexene Diepoxide[J]. Laboratory Animal and Comparative Medicine, 2016, 36(5): 404-408.

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