丙型肝炎病毒动物模型的研究和应用进展

doi:10.3969/j.issn.1674-5817.2013.05.018

摘要/Abstract

摘要： 丙型肝炎病毒(HCV)是导致慢性肝炎、肝硬化和肝细胞肝癌的重要病因之一。HCV感染对全球约1.7亿人造成影响, 并且处于肝硬化和肝细胞肝癌的发病风险中。对HCV敏感性较高的物种主要局限于人类和灵长类动物。缺乏稳定的易感动物模型, 极大限制了对HCV的感染机制、变异、复制、翻译以及与机体之间的作用关系的研究。本文就HCV动物模型研究和应用进展作一综述。

关键词: 丙型肝炎病毒(HCV), 动物模型

Abstract: Hepatitis C virus (HCV) is one of the major causes of the chronic hepatitis, cirrhosis and hepatocellular carcinoma, affecting more than 170 million people worldwide. The most sensitive species to HCV are restricted to humans and primates. The study on HCV infection mechanism, variation, replication, translation and interaction between the virus and human body were limited for lack of stable sensitive animal models. This review introduces the progress of research and application in HCV animal model.

Key words: Hepatitis C virus, Animal model

中图分类号:

Q95-33

于耀程, 汪爱勤, 尹文, 胡兴斌. 丙型肝炎病毒动物模型的研究和应用进展[J]. 实验动物与比较医学, 2013, 33(5): 411-414.

YU Yao-cheng, WANG Ai-qin, YIN Wen, HU Xing-bin. Progress of Research and Application in Hepatitis C Virus Animal Model[J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 411-414.

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