非洲绿猴在艾滋病研究中的应用进展

doi:10.3969/j.issn.1674-5817.2011.04.021

实验动物与比较医学 ›› 2011, Vol. 31 ›› Issue (4): 308-312.DOI: 10.3969/j.issn.1674-5817.2011.04.021

所属专题：实验动物资源开发与利用

• 综述 • 上一篇

非洲绿猴在艾滋病研究中的应用进展

邱正良¹, 杨贵波², 雷娜², 孙兆增¹, 曾林¹

1.中国人民解放军军事医学科学院实验动物中心, 北京 100071;
2.中国疾病预防控制中心性病艾滋病预防控制中心, 北京 100050

收稿日期:2011-05-16 出版日期:2011-08-25 发布日期:2011-08-25
作者简介:邱正良(1971-), 男, 副研究员, 从事实验动物科研工作
基金资助:
国家自然科学基金(30872324)资助

Progresses on Application of African Green Monkeys in AIDS Researches

QIU Zheng-liang¹, YANG Gui-Bo², LEI Na², SUN Zao-Zheng¹, ZENG Ling¹

1. Laboratory Animal center,Academy of Military Medical sciences, Beijing 100071, China;
2.National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, China

Received:2011-05-16 Online:2011-08-25 Published:2011-08-25

摘要/Abstract

摘要： 人类在人免疫缺陷病毒(human immunodeficiency virus, HIV-1)感染后,通常经过一段潜伏期,进展为艾滋病(acquired immunodeficiency syndromes, AIDS)。非洲绿猴(African green monkeys, AGM)是SIV(simian immunodeficiency virus, SIV)的天然宿主,虽然体内的病毒水平与HIV感染者相似,但不表现出艾滋病症状。因此,探索AGM控制病毒复制和疾病进展的分子机制,可以很好地促进对HIV感染致病机理的认识和AIDS疫苗与治疗方法的研究。本文简要介绍AGM在艾滋病研究中的应用和最新研究进展,为艾滋病动物模型的研究提供更多参考。

关键词: 非洲绿猴, 猿猴类免疫缺陷病毒, 艾滋病动物模型

Abstract: Human infected with human immunodeficiency virus (HIV-1) always progress to AIDS after a variable period of latency. However, African green monkeys (AGM) with high levels of virus do not show any signs of AIDS after natural infection with simian immunodeficiency virus (SIV). This elicited interest of researchers to use AGM in studies on the cellular and molecular mechanisms to control virus replication and disease progression. In this paper, recent progresses in this field were briefly reviewed.

Key words: African green monkeys, Simian immunodeficiency virus, AIDS model

中图分类号:

Q95-33

邱正良, 杨贵波, 雷娜, 孙兆增, 曾林. 非洲绿猴在艾滋病研究中的应用进展[J]. 实验动物与比较医学, 2011, 31(4): 308-312.

QIU Zheng-liang, YANG Gui-Bo, LEI Na, SUN Zao-Zheng, ZENG Ling. Progresses on Application of African Green Monkeys in AIDS Researches[J]. Laboratory Animal and Comparative Medicine, 2011, 31(4): 308-312.

参考文献

[1] Bibollet RF, Brengues C, Galat-Luong A, et al.Genetic diversity of simian immunodeficiency viruses from West African green monkeys: evidence of multiple genotypes within populations from the same geographical locale[J]. J Virol, 1997, 71:307-313.
[2] Sodora DL, Allan JS, Apetrei C, et al.Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts[J]. Nat Med, 2009, 15(8):861-865.
[3] Liovat AS, Jacquelin B, Ploquin MJ, et al.African non human primates infected by SIV - why don't they get sick? Lessons from studies on the early phase of non-pathogenic SIV infection[J]. Curr HIV Res, 2009, 7(1):39-50.
[4] Kanki PJ, Kurth R, Becker W, et al.Antibodies to simian T-lymphotropic retrovirus type III in African green monkeys and recognition of STLV-III viral proteins by AIDS and related sera[J]. Lancet, 1985, 1(8441):1330-1332.
[5] Ohta Y, Masuda T, Tsujimoto H, et al.Isolation of simian immunodeficiency virus from African green monkeys and seroepidemiologic survey of the virus in various non-human primates[J]. Int J Cancer, 1988, 41:115-122.
[6] Huet T, Cheynier R, Meyerhans A, et al.Genetic organization of a chimpanzee lentivirus related to HIV-1[J]. Nature, 1990, 345:356-359.
[7] Daniel MD, Li Y, Naidu YM, et al.Simian immunodeficiency virus from African green monkeys[J]. J Virol, 1988, 62: 4123-4128.
[8] Hirsch VM, Olmsted RA, Murphey-Corb, et al.An African primate lentivirus (SIVsm) closely related to HIV-2[J]. Nature, 1989, 339: 389-392.
[9] Tsujimoto H, Hasegawa A, Maki N, et al.Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill[J]. Nature, 1989, 341: 539-541.
[10] Hirsch, VM, Dapolito GA, Goldstein S, et al. A distinct African lentivirus from Sykes' monkeys[J]. J Virol, 1993, 67: 1517-1528.
[11] Gnanadurai CW, Pandrea I, Parrish NF, et al.Genetic identity and biological phenotype of a transmitted/founder virus representative of nonpathogenic simian immunodeficiency virus infection in African green monkeys[J]. J Virol, 2010, 84(23):12245-12254.
[12] Li Y, Naidu YM, Daniel MD, et al.Extensive genetic variability of simian immunodeficiency virus from African green monkeys[J]. J Virol, 1989, 63:1800-1802.
[13] Jubier-Maurin V, Sarni-Manchado P, Veas F, et al.Regulatory genes of simian immunodeficiency viruses from west African green monkeys (Cercopithecus aethiops sabaeus)[J]. J Virol, 1995, 69:7349-7353.
[14] Skasko M, Diamond TL, Kim B.Mechanistic variations among reverse transcriptases of simian immunodeficiency virus variants isolated from African green monkeys[J]. Biochemistry, 2009, 48(23):5389-5395.
[15] Hahn BH, Shaw GM, De Cock KM, et al.AIDS as a zoonosis: scientific and public health implications[J]. Science, 2000, 287:607-614.
[16] Paiardini M.Th17 cells in natural SIV hosts[J]. Curr Opin HIV AIDS, 2010, 5(2):166-172.
[17] Hartung S, Boller K, Cichutek K, et al.Quantitation of a lentivirus in its natural host: simian immunodeficiency virus in African green monkeys[J]. J Virol, 1992, 66:2143-2149.
[18] Pandrea I, Ribeiro RM, Gautam R, et al.Simian immunodeficiency virus SIVagm dynamics in African green monkeys[J]. J Virol, 2008, 82:3713-3724.
[19] Ennen J, Findeklee H, Dittmar MT, et al.CD8+ T lymphocytes of African green monkeys secrete an immunodeficiency virus-suppressing lymphokine[J]. Proc Natl Acad Sci U S A, 1994, 91:7207-7211.
[20] Jacquelin B, Mayau V, Targat B, et al.Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response[J]. J Clin Invest, 2009, 119, 3544-3555.
[21] Zahn RC, Rett MD, Korioth-Schmitz B, et al.Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm[J]. J Virol, 2008, 82:11577-11588.
[22] Zahn RC, Rett MD, Li M, et al.Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease[J]. Blood,2010, 115: 3070-3078.

非洲绿猴在艾滋病研究中的应用进展

Progresses on Application of African Green Monkeys in AIDS Researches

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	赵亚, 张彩勤, 孟寒, 秦靖, 白冰, 赵勇, 葛煦, 师长宏. 课程思政视域下实验动物学教学实践探索[J]. 实验动物与比较医学, 2023, 43(6): 641-646.
[2]	刘欣, 石少波, 张翠, 杨波, 曲川. 小鼠自体动静脉内瘘端侧吻合模型的建立与评价[J]. 实验动物与比较医学, 2023, 43(6): 595-603.
[3]	聂永强, 王朝霞. 濒危基因编辑小鼠品系拯救技术及其应用探讨[J]. 实验动物与比较医学, 2023, 43(6): 636-640.
[4]	赵勇. 实验动物管理工作的沿革与展望——以上海市近10年发展为例[J]. 实验动物与比较医学, 2023, 43(5): 492-503.
[5]	冯丽萍, 朱琦, 林金杏. 实验用鱼的福利研究现状及思考[J]. 实验动物与比较医学, 2023, 43(5): 524-530.
[6]	林金杏, 王新栋, 白雪兵, 冯丽萍, 谢淑武, 陈秋生. 成年斑马鱼体肾的微细结构及其外泌体的分布鉴定[J]. 实验动物与比较医学, 2023, 43(5): 531-540.
[7]	赵丽亚, 倪丽菊, 张彩勤, 汤建平, 姚养正, 聂艳艳, 顾晓雪, 赵莹. 基于多重PCR-LDR技术建立近交系大鼠单核苷酸多态性遗传检测方案[J]. 实验动物与比较医学, 2023, 43(5): 548-558.
[8]	张淑珍, 赵彦光. 实验小型猪生产和使用现状调研报告[J]. 实验动物与比较医学, 2023, 43(5): 559-565.
[9]	于灵芝, 谢建芸, 冯丽萍, 魏晓锋. 金黄色葡萄球菌荧光定量PCR检测方法的建立及其在大鼠、小鼠粪便检测中的应用[J]. 实验动物与比较医学, 2023, 43(5): 566-573.
[10]	王成稷, 王珏, 王海杰, 陆炜晟, 史岩, 顾正页, 万鸣秋, 沈如凌. 乳胶血管灌注技术制作小鼠头面部静脉血管模型方法初探[J]. 实验动物与比较医学, 2023, 43(5): 574-578.
[11]	郭连香. 实验动物微生物、寄生虫学等级及监测标准的变化及与国外标准的比较[J]. 实验动物与比较医学, 2023, 43(4): 339-346.
[12]	黄缨, 韦思羽, 蔡莉, 强苏静, 李冬婷, 丁玉强. 供应商来源的实验大鼠和小鼠微生物监测结果分析：以复旦大学实验动物科学部为例[J]. 实验动物与比较医学, 2023, 43(4): 347-354.
[13]	卞新彦, 陆勇, 王燕, 孙强. 食蟹猴分娩行为分析[J]. 实验动物与比较医学, 2023, 43(4): 355-362.
[14]	邓亚胜, 林江, 甘池伶, 曾官凤, 黄嘉茵, 邓慧芳, 麻颖贤, 韩丝银. 皮肤光老化动物模型制备要素和受试物数据的文献分析[J]. 实验动物与比较医学, 2023, 43(4): 406-414.
[15]	成慧, 方菲, 石嘉豪, 杨桦, 张梦杰, 杨平, 费俭. hil-1基因通过饮食限制通路调节秀丽隐杆线虫寿命[J]. 实验动物与比较医学, 2023, 43(3): 271-281.