非洲绿猴在艾滋病研究中的应用进展

doi:10.3969/j.issn.1674-5817.2011.04.021

实验动物与比较医学 ›› 2011, Vol. 31 ›› Issue (4): 308-312.DOI: 10.3969/j.issn.1674-5817.2011.04.021

所属专题：实验动物资源开发与利用

• 综述 • 上一篇

非洲绿猴在艾滋病研究中的应用进展

邱正良¹, 杨贵波², 雷娜², 孙兆增¹, 曾林¹

1.中国人民解放军军事医学科学院实验动物中心, 北京 100071;
2.中国疾病预防控制中心性病艾滋病预防控制中心, 北京 100050

收稿日期:2011-05-16 出版日期:2011-08-25 发布日期:2011-08-25
作者简介:邱正良(1971-), 男, 副研究员, 从事实验动物科研工作
基金资助:
国家自然科学基金(30872324)资助

Progresses on Application of African Green Monkeys in AIDS Researches

QIU Zheng-liang¹, YANG Gui-Bo², LEI Na², SUN Zao-Zheng¹, ZENG Ling¹

1. Laboratory Animal center,Academy of Military Medical sciences, Beijing 100071, China;
2.National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, China

Received:2011-05-16 Published:2011-08-25 Online:2011-08-25

摘要/Abstract

摘要： 人类在人免疫缺陷病毒(human immunodeficiency virus, HIV-1)感染后,通常经过一段潜伏期,进展为艾滋病(acquired immunodeficiency syndromes, AIDS)。非洲绿猴(African green monkeys, AGM)是SIV(simian immunodeficiency virus, SIV)的天然宿主,虽然体内的病毒水平与HIV感染者相似,但不表现出艾滋病症状。因此,探索AGM控制病毒复制和疾病进展的分子机制,可以很好地促进对HIV感染致病机理的认识和AIDS疫苗与治疗方法的研究。本文简要介绍AGM在艾滋病研究中的应用和最新研究进展,为艾滋病动物模型的研究提供更多参考。

关键词: 非洲绿猴, 猿猴类免疫缺陷病毒, 艾滋病动物模型

Abstract: Human infected with human immunodeficiency virus (HIV-1) always progress to AIDS after a variable period of latency. However, African green monkeys (AGM) with high levels of virus do not show any signs of AIDS after natural infection with simian immunodeficiency virus (SIV). This elicited interest of researchers to use AGM in studies on the cellular and molecular mechanisms to control virus replication and disease progression. In this paper, recent progresses in this field were briefly reviewed.

Key words: African green monkeys, Simian immunodeficiency virus, AIDS model

中图分类号:

Q95-33

邱正良,杨贵波,雷娜,等. 非洲绿猴在艾滋病研究中的应用进展[J]. 实验动物与比较医学, 2011, 31(4): 308-312. DOI: 10.3969/j.issn.1674-5817.2011.04.021.

QIU Zheng-liang,YANG Gui-Bo,LEI Na,et al. Progresses on Application of African Green Monkeys in AIDS Researches[J]. Laboratory Animal and Comparative Medicine, 2011, 31(4): 308-312. DOI: 10.3969/j.issn.1674-5817.2011.04.021.

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非洲绿猴在艾滋病研究中的应用进展

Progresses on Application of African Green Monkeys in AIDS Researches

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