小鼠树突状细胞亚群分类及其比较研究进展

doi:10.12300/j.issn.1674-5817.2020.052

摘要/Abstract

摘要： 以小鼠为代表的啮齿类实验动物一直以来作为人类探索树突状细胞（dendritic cells,DCs）系统的有力工具活跃在各个研究平台。早期人们对于DCs的了解主要来源于对小鼠模型的研究,并根据其表面标志、细胞形成和迁移特性等进行初步分类。目前,小鼠不同DCs亚群的分类方法还没有完全统一,这大大阻碍了人们对DCs的进一步研究与利用。因此需要深入开展小鼠DCs亚群的基础研究,寻找科学、有效、公认的DCs分类方法定义不同的亚群。本文从小鼠DCs细胞亚群分类方法、常见细胞类型、特性及与人类DCs的比较等方面进行综述,阐述目前小鼠DCs亚群分类及特性的研究现状,同时总结了目前待解决的问题。为深入了解DCs亚群的功能及特性提供参考,并期望通过总结亚群相关的问题提出研究方向。

关键词: 树突状细胞, 细胞亚群, 分类, 小鼠

Abstract: Mouse, a representative rodent laboratory animal, has always been a powerful tool for studying dendritic cell (DC) systems. Our current knowledge of DCs has been largely derived from studies of murine models, and according to surface markers, cell development, and migratory characteristics, DCs can be categorized with respect to their subsets. To date, there is no uniform classification scheme for mouse DC subsets, which has greatly hindered research involving DCs. Thus, we believe that basic studies to define murine DC subsets are still needed, and it is crucial to seek scientific, effective, and recognized methods to establish categorical definitions. This review proposed a schema incorporating the classification, phenotypes, and characteristics of murine DC subsets, and compares them with human DC counterparts. The aim is to clarify the classification and characteristics of the current status of DC subsets in mice and summarize the existing challenges. This would be beneficial for gaining an in-depth understanding of the function of DC subsets and would provide novel research directions for DC subset categorizations.

Key words: Dendritic cells, Cell subsets, Classification, Mice

中图分类号:

R-332
Q95-33

阮蕾颖, 孙晓梅. 小鼠树突状细胞亚群分类及其比较研究进展[J]. 实验动物与比较医学, 2021, 41(2): 174-180.

RUAN Leiying, SUN Xiaomei. Classification and Research Progress on Dendritic Cell Subsets in Mice[J]. Laboratory Animal and Comparative Medicine, 2021, 41(2): 174-180.

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