大鼠自发性及药物相关性胰岛纤维化研究进展

doi:10.3969/j.issn.1674-5817.2019.03.014

摘要/Abstract

摘要： 胰岛纤维化是大鼠常见的自发性疾病,随着年龄的增长,病变发生率逐渐升高,且雄性发生率高于雌性。该病的发病原因及机制目前尚未定论。许多药物也能引起或加重大鼠胰岛纤维化,胰岛血管损伤被认为与该病变的发生相关。本文综述了大鼠自发性及药物相关性胰岛纤维化的研究,为实验动物研究及毒性病理学家提供一定的参考。

关键词: 大鼠, 胰岛纤维化, 自发性, 药物相关

Abstract: Islet fibrosis is a common spontaneous disease in rats. The incidence increased with age as well as that of male was higher than female. The pathogenesis and mechanism of this disease have not been conclusive yet. Many drugs could also induce or increase fibrosis in pancreatic islets in rats. Vascular injury in islet was considered to be associated with the occurrence of the disease. This article summarizes the research of spontaneous and drug related pancreatic islet fibrosis in rats, and provides some references for experimental animal research and toxicological pathologists.

Key words: Rats, Islet fibrosis, Spontaneous, Drug-related

中图分类号:

Q95-33

周飞, 王浩安. 大鼠自发性及药物相关性胰岛纤维化研究进展[J]. 实验动物与比较医学, 2019, 39(3): 249-252.

ZHOU Fei, WANG Hao-an. Review of Spontaneous and Drug-related Islet Fibrosis in Rats[J]. Laboratory Animal and Comparative Medicine, 2019, 39(3): 249-252.

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