中医病症结合的围绝经期综合征动物模型研究进展

doi:10.12300/j.issn.1674-5817.2025.023

实验动物与比较医学 ›› 2025, Vol. 45 ›› Issue (5): 586-595.DOI: 10.12300/j.issn.1674-5817.2025.023

• 实验动物与中医药学专题 • 上一篇下一篇

中医病症结合的围绝经期综合征动物模型研究进展

刘洋¹, 程来洋², 郭中坤³()()

^1.山东中医药大学附属医院妇科, 济南 250011
^2.山东大学齐鲁医院妇产科生殖医学中心, 济南 250012
^3.山东第一医科大学(山东省医学科学院)实验动物学院(省实验动物中心), 济南 250117

收稿日期:2025-02-18 修回日期:2025-06-13 出版日期:2025-10-25 发布日期:2025-10-23
通讯作者:
郭中坤（1988—），男，硕士，助理研究员，研究方向：实验动物疾病模型应用。E-mail： zhongkunguo@126.com。ORCID：0000-0003-4461-7670
作者简介:刘洋（1987—），女，博士，主治医师，研究方向：中西医结合治疗妇产科疾病。E-mail： taianliuyang@126.com
基金资助:
山东省医药卫生科技项目“山奈酚联合尼拉帕利对卵巢癌细胞体内外作用研究”(202305010877);山东省医学科学院医药卫生科技创新工程“精准医疗用实验动物模型的保育、研发与应用项目”

Progress on Animal Models of Perimenopausal Syndrome Based on Traditional Chinese Medicine Disease-Syndrome Combination

LIU Yang¹, CHENG Laiyang², GUO Zhongkun³()()

^1.Department of Gynecology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China
^2.Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan 250012, China
^3.School of Laboratory Animal & Shandong Laboratory Animal Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China

Received:2025-02-18 Revised:2025-06-13 Published:2025-10-25 Online:2025-10-23
Contact: GUO Zhongkun (ORCID: 0000-0003-4461-7670), E-mail: zhongkunguo@126.com

摘要/Abstract

摘要：

围绝经期综合征（perimenopausal syndrome，PS）是女性在绝经前后因雌激素水平减少或波动而出现的月经紊乱、烘热汗出、焦虑抑郁、头痛失眠等一系列生理和心理症状，严重影响生活质量。目前，针对PS的治疗方式主要为绝经激素治疗和中医治疗2种。其中，绝经激素治疗起效速度快，但常常受激素治疗禁忌证和患者接受度的制约。中医治疗则通过整体调节及个体化治疗，在改善潮热、情绪障碍等症状方面具有独特优势，且具有较高的安全性，为不愿或不宜接受绝经激素治疗的患者提供了有效替代选择。然而，中医治疗PS及其并发症的机制阐释不清、循证证据薄弱等问题，限制了其在PS中的进一步应用。因此，构建既能精准模拟复杂证候演变规律，又能系统解析中药多靶点调控机制的病证结合PS 动物模型，对于探究PS发生机制、药物的筛选评价，以及中药复方、中药单体和针灸治疗的效果评估尤为重要。本文从PS的中医病因病机、治疗方法与效果，PS动物模型的建模方法与评价指标，以及动物模型在PS中医治疗中的应用3个方面，对近年来中医病证结合PS 动物模型的最新研究进行总结与分析，不仅为后期应用PS动物模型开展的实验研究提供了科学支撑，而且有助于深化人们对中医治疗PS效果及其作用机制的理解。

关键词: 围绝经期综合征, 动物模型, 中医, 病证结合, 卵巢切除术

Abstract:

Perimenopausal syndrome (PS) is a series of physiological and psychological symptoms occurring in women around menopause due to decreased or fluctuating estrogen levels, including menstrual disorders, hot flashes with sweating, anxiety and depression, headaches and insomnia, which seriously affect their quality of life. Currently, the main treatment methods for PS are menopausal hormone therapy and traditional Chinese medicine (TCM) therapy. Among them, menopausal hormone therapy has a rapid onset of effect, but is often restricted by contraindications to hormone therapy and patient acceptance. TCM therapy, through overall regulation and individualized treatment, has unique advantages in improving symptoms such as hot flashes and emotional disorders, and it has high safety, providing an effective alternative for patients who are unwilling or unsuitable to receive menopausal hormone therapy. However, the unclear explanation of the mechanism and weak evidence-based support for TCM treatment of PS and its complications restrict further application in PS. Therefore, construction of a disease-syndrome combined PS animal model that can accurately simulate complex syndrome evolution patterns and systematically analyze multi-target regulatory mechanisms of TCM is particularly important for investigating PS pathogenesis, drug screening and evaluation, and efficacy assessment of TCM compounds, TCM monomers, and acupuncture treatment. This article summarizes and analyzes recent research on TCM disease-syndrome combined PS animal models from three aspects: the etiology, pathogenesis, treatment methods, and effects; the modeling methods and evaluation indicators of PS animal models; and the application of animal models in TCM treatment of PS. It not only provides scientific support for experimental research using PS animal models in future studies, but also helps deepen the understanding of TCM treatment efficacy and action mechanisms for PS.

Key words: Perimenopausal syndrome, Animal models, Traditional Chinese medicine, Combination of disease and syndrome, Ovariectomy

中图分类号:

R-332

刘洋,程来洋,郭中坤. 中医病症结合的围绝经期综合征动物模型研究进展[J]. 实验动物与比较医学, 2025, 45(5): 586-595. DOI: 10.12300/j.issn.1674-5817.2025.023.

LIU Yang,CHENG Laiyang,GUO Zhongkun. Progress on Animal Models of Perimenopausal Syndrome Based on Traditional Chinese Medicine Disease-Syndrome Combination[J]. Laboratory Animal and Comparative Medicine, 2025, 45(5): 586-595. DOI: 10.12300/j.issn.1674-5817.2025.023.

图/表 3

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中医病症结合的围绝经期综合征动物模型研究进展

Progress on Animal Models of Perimenopausal Syndrome Based on Traditional Chinese Medicine Disease-Syndrome Combination

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