实验动物与比较医学 ›› 2016, Vol. 36 ›› Issue (6): 473-478.DOI: 10.3969/j.issn.1674-5817.2016.06.014
张薇, 唐彬, 黎福荣
收稿日期:
2016-08-25
出版日期:
2016-12-25
发布日期:
2016-12-25
作者简介:
张薇(1964-), 女, 高级实验师, 硕士, 从事中西医结合基础和实验动物研究工作。E-mail: zwygqj@163.com
基金资助:
ZHANG Wei, TANG Bin, LI Fu-rong
Received:
2016-08-25
Online:
2016-12-25
Published:
2016-12-25
摘要: TX 小鼠(toxic milk mouse)是由DL近交系小鼠繁殖到第68 代所产生的自然突变品系。主要表现为低色素化、生长迟缓、震颤和运动功能障碍等,其与Wilson 病的共同点包括: 遗传方式属于常染色体隐性遗传、成年小鼠体内铜大量沉积使血清铜和血清铜蓝蛋白水平降低等特点。文 章从TX 小鼠的病理生理学、致病机理、病理治疗学等多个方面综述了TX小鼠的研究现状。
中图分类号:
张薇, 唐彬, 黎福荣. TX 小鼠研究进展[J]. 实验动物与比较医学, 2016, 36(6): 473-478.
ZHANG Wei, TANG Bin, LI Fu-rong. Research Progress on Toxic Milk Mouse[J]. Laboratory Animal and Comparative Medicine, 2016, 36(6): 473-478.
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