实验动物与比较医学 ›› 2011, Vol. 31 ›› Issue (2): 147-152.DOI: 10.3969/j.issn.1674-5817.2011.02.019

所属专题: 实验动物资源开发与利用

• 综述 • 上一篇    

斑马鱼分子遗传位标及多态性研究进展

赵莹1,2, 沈志敏1,3, 刘雄伟1,3, 魏晓锋1,3, 胡建华1,3   

  1. 1.上海实验动物研究中心,上海 201203;
    2.上海西普尔-必凯实验动物有限公司, 上海 201203;
    3.上海市实验动物质量监督检验站, 上海 201203
  • 收稿日期:2010-07-07 出版日期:2011-04-25 发布日期:2011-04-25
  • 作者简介:赵 莹(1982-), 女, 硕士, 助理研究员, 研究方向: 群体遗传学及药物毒性安全评价,E-mail: gululu29@yahoo.com.cn
  • 基金资助:
    上海市科学技术委员会创新行动计划项目(NO.0714090002)

Progress on Molecular Markers for Zebrafish and Polymorphism in Zebrafish Strains

ZHAO Ying1,2, SHEN Zhi-min1,3, LIU Xiong-wei1,3, WEI Xiao-feng1,3, HU Jian-hua1,3   

  1. 1. Shanghai Laboratory Animal Research Center, Shanghai 201203, China;
    2. Sino-British SIPPR / BK Lab.Animal LTD, CO, Shanghai 201203, China;
    3. Shanghai Quality Monitoning Center for Lab.Animals, Shanghai 201203, China
  • Received:2010-07-07 Online:2011-04-25 Published:2011-04-25

摘要: 过去二十年间,分子遗传位标可揭示DNA水平的多态性,在斑马鱼的遗传研究中所占比重越来越大。本文介绍分子遗传位标及斑马鱼遗传图谱,探讨这些遗传位标使用时的优缺点,展示斑马鱼品系的多态性。

关键词: 分子遗传位标, RAPD, SSCP, STR, SNP, 多态性, 斑马鱼

Abstract: During the last twenty years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in zebrafish genetics studies. In this review, the molecular markers and genetic maps for zebrafish was introduced, the advantages and disadvantages of using these markers was discussed, and the polymorphism in zebrafish strains was described.

Key words: Molecular marker, RAPD, SSCP, STR, SNP, Polymorphism, Zebrafish

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