《动物研究：体内实验报告》即ARRIVE 2.0指南的解释和阐述（五）

doi:10.12300/j.issn.1674-5817.2023.146

实验动物与比较医学 ›› 2024, Vol. 44 ›› Issue (1): 105-114.DOI: 10.12300/j.issn.1674-5817.2023.146

• 比较医学研究与报告规范 • 上一篇下一篇

《动物研究：体内实验报告》即ARRIVE 2.0指南的解释和阐述（五）

马政文¹()(), 李夏莹², 刘晓宇³, 李垚¹, 王剑¹, 卢今¹, 陈国元⁴, 卢晓⁵, 白玉⁶, 卢选成⁷, 刘永刚⁸, 庞万勇¹⁰()(), 陶雨风⁹()()

^1.上海交通大学医学院实验动物科学部, 上海 200025
^2.北京大学生命科学学院实验动物中心, 北京 100871
^3.中国疾病预防控制中心职业卫生与中毒控制所, 北京 100050
^4.中国科学院分子细胞科学卓越创新中心动物实验技术平台, 上海 200031
^5.迪哲医药股份有限公司, 上海 201203
^6.北京诺和诺德医药科技有限公司, 北京 102206
^7.中国疾病预防控制中心, 传染病溯源预警与智能决策全国重点实验室, 北京 102206
^8.中国农业科学院哈尔滨兽医研究所, 哈尔滨 150001
^9.中国合格评定国家认可中心, 北京 100062
^10.赛诺菲公司全球研发中心转化体内模型研究平台, 北京 100022

收稿日期:2023-10-23 修回日期:2023-12-23 出版日期:2024-02-25 发布日期:2024-03-08
通讯作者: 陶雨风（1970—），女，博士，高级工程师，研究方向：分子免疫学。E-mail： taoyf@cnas.org.cn。ORCID：0000-0003-1925-1048；
庞万勇（1974—），男，兽医学博士，研究方向：实验动物医学。E-mail: pang1yong@outlook.com。ORCID：0000-0002-0724-2016
作者简介:马政文（1972—），女，博士，副研究员，研究方向：神经生物学、实验动物医学。E-mail： mazhengwen@shsmu.edu.cn。ORCID：0009-0001-6224-5789
基金资助:
国家重点研发计划“实验动物共性关键质量评价技术标准研究”(2022YFF0711000);中国科学技术期刊编辑学会2023年翰笔计划医学中青年编辑科研项目“动物实验医学研究及报告规范化的国际对标（指南汉化推广）”(HBJH-2023-A16)

Interpretation and Elaboration for the ARRIVE Guidelines 2.0—Animal Research: Reporting In Vivo Experiments (V)

Zhengwen MA¹()(), Xiaying LI², Xiaoyu LIU³, Yao LI¹, Jian WANG¹, Jin LU¹, Guoyuan CHEN⁴, Xiao LU⁵, Yu BAI⁶, Xuancheng LU⁷, Yonggang LIU⁸, Wanyong PANG¹⁰()(), Yufeng TAO⁹()()

^1.Department of Laboratory Animal Science, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
^2.Peking University, School of Life Science, laboratory research Center, Beijing 100871, China
^3.National Institute for Occupational Health and Poison Control, Beijing 100050, China
^4.Center for Excellence in Molecular Cell Science, Chinese Academy of Science, Shanghai 200031, China
^5.Dizal Pharmaceuticals Co. , Ltd. , Shanghai 201203, China
^6.Novo Nordisk Research Centre China, Beijing 102206, China
^7.National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), Chinese Center for Disease Control and Prevention, Beijing 102206, China
^8.Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China
^9.China National Accreditation Service for Conformity Assessment, Beijing 100062, China
^10.Translational in Vivo Model Research Platform, Sanofi G&D, Beijing 100022, China

Received:2023-10-23 Revised:2023-12-23 Published:2024-02-25 Online:2024-03-08
Contact: TAO Yufeng (ORCID: 0000-0003-1925-1048), E-mail:taoyf@cnas.org.cn;
PANG Wanyong (ORCID： 0000-0002-0724-2016), E-mail:pang1yong@outlook.com

摘要/Abstract

摘要：

提高生物医学研究结果的可重复性是一项重大挑战，研究人员透明且准确地报告其研究过程有利于读者对该研究结果的可靠性进行评估，进而重复该实验或在该成果的基础上进一步探索。ARRIVE 2.0指南是英国国家 3Rs中心（NC3Rs）于2019年组织发布的一份适用于任何与活体动物研究报告相关的指导性清单，用以提高动物体内实验设计、实验实施和实验报告的规范性，以及动物实验结果的可靠性、可重复性和临床转化率。ARRIVE 2.0指南的使用不仅可以丰富动物实验研究报告的细节，确保动物实验结果信息被充分评估和利用，还可以使读者准确且清晰地了解作者所表述的内容，促进基础研究评审过程的透明化和完整性。本文是在国际期刊遵循ARRIVE 2.0指南的最佳实践基础上，对2020年发表于PLoS Biology期刊上的ARRIVE 2.0指南完整解读版（https：//arriveguidelines.org）第五部分包括“推荐11条”里的第6～11条：“动物照护和监测”、“解析/科学阐释”、“可推广性/转化”、“研究方案注册”、“数据获取”和“利益冲突声明”等内容进行了编译、解释和阐述，以期促进国内研究人员充分理解并使用ARRIVE 2.0指南，提高实验动物研究及报告的规范性，助推我国实验动物科技与比较医学研究的高质量发展。

关键词: 动物实验, ARRIVE 2.0指南, ARRIVE推荐11条, 疼痛管理, 动物照护和监测

Abstract:

Improving the reproducibility of biomedical research results is a major challenge. Transparent and accurate reporting of the research process enables readers to evaluate the reliability of the research results and further explore the experiment by repeating it or building upon its findings. The ARRIVE 2.0 guidelines, released in 2019 by the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), provide a checklist that is applicable to any in vivo animal research report. These guidelines aim to improve the standardization of experimental design, implementation, and reporting, as well as enhance the reliability, repeatability, and clinical translation of animal experimental results. The use of the ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports, ensuring that information on animal experimental results is fully evaluated and utilized, but also enables readers to understand the content expressed by the author accurately and clearly, promoting the transparency and completeness of the fundamental research review process. At present, the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals. This article is based on the best practices following the ARRIVE 2.0 guidelines in international journals, and it interprets, explains, and elaborates in Chinese the fifth part of the comprehensive version of the ARRIVE 2.0 guidelines published in PLoS Biology in 2020 (the original text can be found at https://arriveguidelines.org). This section includes the items 6-11 of Recommended 11 section, covering "Animal Care and Monitoring", "Interpretation/Scientific Implications", "Generalisability/Translation", "Protocol Registration", "Data Access" and "Declaration of Interests". Its aim is to promote a comprehensive understanding and use of the ARRIVE 2.0 guidelines among domestic researchers, to enhance the standardization of experimental animal research and reporting, and to promote high-quality development of experimental animal sciences and comparative medicine research in China.

Key words: Animal experiment, ARRIVE 2.0 guidelines, ARRIVE Recommended set, Pain management, Animal care and monitoring

中图分类号:

R-332

马政文, 李夏莹, 刘晓宇, 李垚, 王剑, 卢今, 陈国元, 卢晓, 白玉, 卢选成, 刘永刚, 庞万勇, 陶雨风. 《动物研究：体内实验报告》即ARRIVE 2.0指南的解释和阐述（五）[J]. 实验动物与比较医学, 2024, 44(1): 105-114.

Zhengwen MA, Xiaying LI, Xiaoyu LIU, Yao LI, Jian WANG, Jin LU, Guoyuan CHEN, Xiao LU, Yu BAI, Xuancheng LU, Yonggang LIU, Wanyong PANG, Yufeng TAO. Interpretation and Elaboration for the ARRIVE Guidelines 2.0—Animal Research: Reporting In Vivo Experiments (V)[J]. Laboratory Animal and Comparative Medicine, 2024, 44(1): 105-114.

图/表 1

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《动物研究：体内实验报告》即ARRIVE 2.0指南的解释和阐述（五）

Interpretation and Elaboration for the ARRIVE Guidelines 2.0—Animal Research: Reporting In Vivo Experiments (V)

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