甲型流感病毒对人与实验动物神经系统影响的研究进展

doi:10.12300/j.issn.1674-5817.2022.142

实验动物与比较医学 ›› 2023, Vol. 43 ›› Issue (2): 180-185.DOI: 10.12300/j.issn.1674-5817.2022.142

甲型流感病毒对人与实验动物神经系统影响的研究进展

丁相荣¹(), 霍姝汭², 代解杰¹()()

^1.中国医学科学院/北京协和医学院医学生物学研究所, 昆明 650118
^2.昆明医科大学, 昆明 650500

收稿日期:2022-09-02 修回日期:2022-12-17 出版日期:2023-04-25 发布日期:2023-05-16
通讯作者: 代解杰（1961—），男，博士生导师，研究方向：人类疾病动物模型建立与比较医学。E-mail：djj@imbcams.com.cn。ORCID：0000-0002-4242-9089
作者简介:丁相荣（1997—），女，硕士研究生，研究方向：人类疾病动物模型及机制研究。E-mail：dxr00912@163.com
基金资助:
云南省科技人才和平台计划项目“中国医学科学院医学生物学研究所实验树鼩标准化与应用研究省创新团队”(2017HC019)

Research Progress on Influenza A Virus and Nervous System Disease of Human and Experimental Animals

Xiangrong DING¹(), Shurui HUO², Jiejie DAI¹()()

^1.Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China
^2.Kunming Medical University, Kunming 650500, China

Received:2022-09-02 Revised:2022-12-17 Published:2023-04-25 Online:2023-05-16
Contact: DAI Jiejie (ORCID: 0000-0002-4242-9089), E-mail: djj@imbcams.com.cn

摘要/Abstract

摘要：

流感作为一种高度传染性疾病，主要影响呼吸系统，常导致肺部并发症，但它也会导致多种罕见却严重的神经系统并发症，包括格林-巴利综合征、横贯性脊髓炎、脑膜脑炎等。近年来，多个国家和地区相继报告了甲型流感病毒引起的神经系统并发症病例，逐渐引起国际关注。然而该并发症的发病机制尚不清楚，相关病例及动物实验科学研究较少，无特定疗法。本文围绕人与实验动物感染甲型流感病毒后神经系统并发症的研究进展进行归纳总结，以期对甲型流感病毒引起的神经系统性疾病有一个全面的认识和理解。

关键词: 甲型流感病毒, 神经系统并发症, 动物实验

Abstract:

Influenza is a highly contagious disease that mainly affects the respiratory system and often leads to lung complications. Also it can cause a variety of very rare and serious neurological complications, including Guillain-Barre syndrome, transverse myelitis, meningoencephalitis and others. In recent years, neurological complications caused by influenza A virus have been reported in many countries and regions, and gradually attracted international attention. However, the pathogenesis of this complication remains unclear, and there are few related cases and animal experimental studies,and no specific treatment. Therefore, the authors summarized the study of neurological complications caused by influenza A virus in human and laboratory animals, in order to have a comprehensive understanding of the neurological diseases caused by influenza A virus.

Key words: Influenza A virus, Neurological complications, Animal experiment

中图分类号:

R-332

丁相荣, 霍姝汭, 代解杰. 甲型流感病毒对人与实验动物神经系统影响的研究进展[J]. 实验动物与比较医学, 2023, 43(2): 180-185.

Xiangrong DING, Shurui HUO, Jiejie DAI. Research Progress on Influenza A Virus and Nervous System Disease of Human and Experimental Animals[J]. Laboratory Animal and Comparative Medicine, 2023, 43(2): 180-185.

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甲型流感病毒对人与实验动物神经系统影响的研究进展

Research Progress on Influenza A Virus and Nervous System Disease of Human and Experimental Animals

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