《动物研究：体内实验报告》即ARRIVE 2.0指南的解释和阐述（二）

doi:10.12300/j.issn.1674-5817.2023.042

实验动物与比较医学 ›› 2023, Vol. 43 ›› Issue (3): 323-331.DOI: 10.12300/j.issn.1674-5817.2023.042

所属专题：动物实验设计及统计学方法

• 比较医学研究与报告规范 • 上一篇下一篇

《动物研究：体内实验报告》即ARRIVE 2.0指南的解释和阐述（二）

陈国元¹, 卢晓²(), 白玉³, 于灵芝⁴, 乔颖³, 王剑⁵, 卢今⁵, 刘晓宇⁶, 卢选成⁷, 高静⁸, 李垚⁵, 庞万勇⁹()()

^1.中国科学院分子细胞科学卓越创新中心动物实验技术平台, 上海 200031
^2.迪哲医药股份有限公司, 上海 201203
^3.北京诺和诺德医药科技有限公司, 北京 102206
^4.上海实验动物研究中心, 上海 201203
^5.上海交通大学医学院实验动物科学部, 上海 200025
^6.中国疾病预防控制中心职业卫生与中毒控制所, 北京 100050
^7.中国疾病预防控制中心, 北京 102206
^8.上海交通大学医学院临床研究中心, 上海 200025
^9.赛诺菲公司全球研发中心转化体内模型研究平台, 北京 100022

收稿日期:2023-03-30 修回日期:2023-06-18 出版日期:2023-06-25 发布日期:2023-07-18
通讯作者: 庞万勇（1974—），男，博士，研究方向：实验动物医学。E-mail： pang1yong@outlook.com。ORCID：0000-0002-0724-2016
作者简介:陈国元（1977—），男，博士，高级工程师，研究方向：实验动物模型。E-mail： chenguoy@sibcb.ac.cn
卢晓（1981—），男，博士，研究方向：实验动物医学。E-mail：Frank.Lu@dizalpharma.com。ORCID: 0000-0003-2236-027X
白玉（1981—），女，博士，研究方向：实验动物医学。E-mail：caubaiyu@hotmail.com
对本文贡献相等。

Explanation and Elaboration of the ARRIVE Guidelines 2.0—Reporting Animal Research and In Vivo Experiments (Ⅱ)

Guoyuan CHEN¹, Xiao LU²(), Yu BAI³, Lingzhi YU⁴, Ying QIAO³, Jian WANG⁵, Jin LU⁵, Xiaoyu LIU⁶, Xuancheng LU⁷, Jing GAO⁸, Yao LI⁵, Wanyong PANG⁹()()

^1.Animal Core Facility, Center for Excellence in Molecular Cell Science, Chinese Academy of Science, Shanghai 200031, China
^2.Dizal Pharmaceuticals Co. , Ltd. , Shanghai 201203, China
^3.Novo Nordisk Research Centre China, Beijing 102206, China
^4.Shanghai Laboratory Animal Research Center, Shanghai 201203, China
^5.Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
^6.National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China
^7.Laboratory Animal Center, Chinese Center for Disease Control and Prevention, Beijing 102206, China
^8.Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
^9.Translational in Vivo Model Research Platform, Sanofi G&D, Beijing 100022, China

Received:2023-03-30 Revised:2023-06-18 Published:2023-06-25 Online:2023-07-18
Contact: PANG Wanyong (ORCID: 0000-0002-0724-2016), E-mail: pang1yong@outlook.com

摘要/Abstract

摘要：

提高生物医学研究结果的可重复性是一项重大挑战，研究人员透明且准确地报告其研究过程有利于读者评估该研究结果的可靠性，进而重复该实验或在该成果的基础上进一步探索。ARRIVE 2.0指南是英国国家3Rs中心（NC3Rs）于2019年组织发布的一份适用于任何与活体动物研究报告相关的指导性清单，用以提高动物体内实验设计、实验实施和实验报告的规范性，以及动物实验结果的可靠性、可重复性和临床转化率。ARRIVE 2.0指南的使用不仅可以丰富动物实验研究报告的细节，确保动物实验结果信息被充分评估和利用，还可以使读者准确且清晰地了解作者所表述的内容，促进基础研究评审过程的透明化和完整性。目前，ARRIVE 2.0指南已经被国际生物医学期刊广泛采纳。本文是在国际期刊遵循ARRIVE 2.0指南的最佳实践基础上，对2020年发表于PLoS Biology期刊上的ARRIVE 2.0指南完整解读版（原文请见https：//arriveguidelines.org）进行中文编译（第二部分包括“关键10条”里的第4～7条：“随机化”、“盲法”、“结果测量”和“统计方法”等部分），以期促进国内研究人员充分理解并使用ARRIVE 2.0指南，提高实验动物研究及报告的规范性，助推我国实验动物科技与比较医学研究的高质量发展。

关键词: 动物实验, ARRIVE 2.0指南, ARRIVE关键10条, 随机化, 盲法, 结果测量, 统计方法

Abstract:

Improving the reproducibility of biomedical research results remains a major challenge. Transparent and accurate reporting of progress can help readers evaluate the reliability of research results and further explore an experiment by repeating or building upon its findings. The ARRIVE 2.0 guidelines, released in 2019 by the UK National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs), provide a checklist applicable to any in vivo animal research report. These guidelines aim to improve the standardization of experimental design, implementation, and reporting, as well as the reliability, repeatability, and clinical translatability of animal experimental results. The use of the ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports, ensuring that information on animal experimental results is fully evaluated and utilized, but also enables readers to understand the content expressed by the author accurately and clearly, promoting the transparency and integrity of the fundamental research review process. At present, the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals. This article is the second part of the Chinese translation of the complete interpretation of the ARRIVE 2.0 guidelines published in PLoS Biology in 2020 (original text can be found at https://arriveguidelines.org) and based on the best practices for following the ARRIVE 2.0 guidelines in international journals. This part includes Items 4-7 of "ARRIVE Essential 10" in the ARRIVE 2.0 guidelines: "Randomization", "Blinding", "Outcome Measurement", and "Statistical Methods". Our Chinese translated version aims to promote the full understanding and use of the ARRIVE 2.0 guidelines by domestic researchers, enhancing the standardization of experimental animal research and reporting, and promoting the high-quality development of experimental animal technology and comparative medicine research in China.

Key words: Animal experiment, ARRIVE 2.0 guidelines, ARRIVE Essential 10, Randomization, Blinding, Outcome measurement, Statistical methods

中图分类号:

R-332

陈国元, 卢晓, 白玉, 于灵芝, 乔颖, 王剑, 卢今, 刘晓宇, 卢选成, 高静, 李垚, 庞万勇. 《动物研究：体内实验报告》即ARRIVE 2.0指南的解释和阐述（二）[J]. 实验动物与比较医学, 2023, 43(3): 323-331.

Guoyuan CHEN, Xiao LU, Yu BAI, Lingzhi YU, Ying QIAO, Jian WANG, Jin LU, Xiaoyu LIU, Xuancheng LU, Jing GAO, Yao LI, Wanyong PANG. Explanation and Elaboration of the ARRIVE Guidelines 2.0—Reporting Animal Research and In Vivo Experiments (Ⅱ)[J]. Laboratory Animal and Comparative Medicine, 2023, 43(3): 323-331.

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《动物研究：体内实验报告》即ARRIVE 2.0指南的解释和阐述（二）

Explanation and Elaboration of the ARRIVE Guidelines 2.0—Reporting Animal Research and In Vivo Experiments (Ⅱ)

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