胎儿宫内生长受限动物模型的研究进展

doi:10.12300/j.issn.1674-5817.2022.063

实验动物与比较医学 ›› 2022, Vol. 42 ›› Issue (5): 423-431.DOI: 10.12300/j.issn.1674-5817.2022.063

胎儿宫内生长受限动物模型的研究进展

胡祺雯¹^,²(), 毕正¹^,², 刘海萍¹, 董志华¹, 朱燕林¹, 王进华¹()()

^1.江西省妇幼保健院医学影像中心, 南昌 330000
^2.南昌大学医学院, 南昌 330000

收稿日期:2022-05-11 修回日期:2022-07-26 出版日期:2022-10-25 发布日期:2022-10-25
通讯作者: 王进华（1972—），男，博士，副主任医师，副教授，硕士生导师，主要从事妇产科、儿科影像诊断以及血管介入治疗工作。E-mail： wangjinhua80119@163.com。ORCID：0000-0002-3442-6259
作者简介:胡祺雯（1997—），女，硕士研究生，主要从事影像诊断研究。E-mail：mkyhu@outlook.com
基金资助:
江西省卫生健康委科技计划"探讨MR多模态成像对胎儿手结构性畸形的预测价值”(SKJP220201533)

Research Progress on Animal Models of Intrauterine Growth Restriction

Qiwen HU¹^,²(), Zheng BI¹^,², Haiping LIU¹, Zhihua DONG¹, ZHUYanlin¹, Jinhua WANG¹()()

^1.Radiology department, Jiangxi Maternal and Child Health Hospital, Nanchang 330000, China
^2.Mediccal College, Nanchang University, Nanchang 330000, China

Received:2022-05-11 Revised:2022-07-26 Published:2022-10-25 Online:2022-10-25
Contact: WANG Jinhua (ORCID:0000-0002-3442-6259), E-mail: wangjinhua80119@163.com

摘要/Abstract

摘要：

宫内生长受限（intrauterine growth restriction，IUGR）的发生可能与母体营养不良、胎盘功能异常、免疫异常、遗传相关问题以及其他疾病有关，但其机制尚不明确。因此，IUGR的研究以及其动物模型相关研究的发展是产科学中的关键问题。IUGR模型以实验啮齿类动物如小鼠、大鼠，以及部分哺乳类动物如猪、兔、羊为主要造模动物。本文介绍几种常用的IUGR模型，包括营养限制模型、高海拔妊娠模型、自然选择模型、尼古丁暴露模型等，并描述各种模型的构建方法，比较它们的优缺点。

关键词: 动物模型, 宫内生长受限, 研究进展

Abstract:

The occurrence of intrauterine growth restriction (IUGR) may be related to maternal malnutrition, abnormal placental function, immune abnormalities, genetically related problems as well as other diseases, but the mechanism is still unclear. Therefore, the study of IUGR and the development of its animal model are critical issues in obstetrics. IUGR models are mainly based on laboratory rodents, such as mice and rats, and other mammals such as pigs, rabbits and sheep. This article introduced several common IUGR animal models, including nutrition restriction model, high-altitude pregnancy model, natural selection model, and nicotine exposure model, and also described the construction methods of IUGR models and the comparison of their advantages and disadvantages.

Key words: Animal model, Intrauterine growth restriction, Research progress

中图分类号:

R-332

胡祺雯,毕正,刘海萍,等. 胎儿宫内生长受限动物模型的研究进展[J]. 实验动物与比较医学, 2022, 42(5): 423-431. DOI: 10.12300/j.issn.1674-5817.2022.063.

Qiwen HU,Zheng BI,Haiping LIU,et al. Research Progress on Animal Models of Intrauterine Growth Restriction[J]. Laboratory Animal and Comparative Medicine, 2022, 42(5): 423-431. DOI: 10.12300/j.issn.1674-5817.2022.063.

图/表 1

参考文献 71

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胎儿宫内生长受限动物模型的研究进展

Research Progress on Animal Models of Intrauterine Growth Restriction

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