胎儿宫内生长受限动物模型的研究进展

doi:10.12300/j.issn.1674-5817.2022.063

实验动物与比较医学 ›› 2022, Vol. 42 ›› Issue (5): 423-431.DOI: 10.12300/j.issn.1674-5817.2022.063

胎儿宫内生长受限动物模型的研究进展

胡祺雯¹^,²(), 毕正¹^,², 刘海萍¹, 董志华¹, 朱燕林¹, 王进华¹()()

^1.江西省妇幼保健院医学影像中心, 南昌 330000
^2.南昌大学医学院, 南昌 330000

收稿日期:2022-05-11 修回日期:2022-07-26 出版日期:2022-10-25 发布日期:2022-11-04
通讯作者: 王进华（1972—），男，博士，副主任医师，副教授，硕士生导师，主要从事妇产科、儿科影像诊断以及血管介入治疗工作。E-mail： wangjinhua80119@163.com。ORCID：0000-0002-3442-6259
作者简介:胡祺雯（1997—），女，硕士研究生，主要从事影像诊断研究。E-mail：mkyhu@outlook.com
基金资助:
江西省卫生健康委科技计划"探讨MR多模态成像对胎儿手结构性畸形的预测价值”(SKJP220201533)

Research Progress on Animal Models of Intrauterine Growth Restriction

Qiwen HU¹^,²(), Zheng BI¹^,², Haiping LIU¹, Zhihua DONG¹, ZHUYanlin¹, Jinhua WANG¹()()

^1.Radiology department, Jiangxi Maternal and Child Health Hospital, Nanchang 330000, China
^2.Mediccal College, Nanchang University, Nanchang 330000, China

Received:2022-05-11 Revised:2022-07-26 Published:2022-10-25 Online:2022-11-04
Contact: WANG Jinhua (ORCID:0000-0002-3442-6259), E-mail: wangjinhua80119@163.com

摘要/Abstract

摘要：

宫内生长受限（intrauterine growth restriction，IUGR）的发生可能与母体营养不良、胎盘功能异常、免疫异常、遗传相关问题以及其他疾病有关，但其机制尚不明确。因此，IUGR的研究以及其动物模型相关研究的发展是产科学中的关键问题。IUGR模型以实验啮齿类动物如小鼠、大鼠，以及部分哺乳类动物如猪、兔、羊为主要造模动物。本文介绍几种常用的IUGR模型，包括营养限制模型、高海拔妊娠模型、自然选择模型、尼古丁暴露模型等，并描述各种模型的构建方法，比较它们的优缺点。

关键词: 动物模型, 宫内生长受限, 研究进展

Abstract:

The occurrence of intrauterine growth restriction (IUGR) may be related to maternal malnutrition, abnormal placental function, immune abnormalities, genetically related problems as well as other diseases, but the mechanism is still unclear. Therefore, the study of IUGR and the development of its animal model are critical issues in obstetrics. IUGR models are mainly based on laboratory rodents, such as mice and rats, and other mammals such as pigs, rabbits and sheep. This article introduced several common IUGR animal models, including nutrition restriction model, high-altitude pregnancy model, natural selection model, and nicotine exposure model, and also described the construction methods of IUGR models and the comparison of their advantages and disadvantages.

Key words: Animal model, Intrauterine growth restriction, Research progress

中图分类号:

R-332

胡祺雯, 毕正, 刘海萍, 董志华, 朱燕林, 王进华. 胎儿宫内生长受限动物模型的研究进展[J]. 实验动物与比较医学, 2022, 42(5): 423-431.

Qiwen HU, Zheng BI, Haiping LIU, Zhihua DONG, ZHUYanlin, Jinhua WANG. Research Progress on Animal Models of Intrauterine Growth Restriction[J]. Laboratory Animal and Comparative Medicine, 2022, 42(5): 423-431.

图/表 1

参考文献 71

1	LANE S L, DOYLE A S, BALES E S, et al. Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy[J]. FASEB J, 2020, 34(3):4283-4292. DOI:10.1096/fj.201902264RR .
2	CORTES-ARAYA Y, STENHOUSE C, SALAVATI M, et al. KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction[J]. J Physiol, 2022, 600(7):1771-1790. DOI:10.1113/JP281647 .
3	DARENDELILER F. IUGR: Genetic influences, metabolic problems, environmental associations/triggers, current and future management[J]. Best Pract Res Clin Endocrinol Metab, 2019, 33(3):101260. DOI:10.1016/j.beem.2019.01.001 .
4	HUNTER D S, HAZEL S J, KIND K L, et al. Programming the brain: common outcomes and gaps in knowledge from animal studies of IUGR[J]. Physiol Behav, 2016, 164:233-248. DOI:10.1016/j.physbeh.2016.06.005 .
5	GONZALEZ-BULNES A, ASTIZ S, PARRAGUEZ V H, et al. Empowering translational research in fetal growth restriction: sheep and swine animal models[J]. Curr Pharm Biotechnol, 2016, 17(10):848-855. DOI:10.2174/1389201017666-160519111529 .
6	MORRISON J L, BERRY M J, BOTTING K J, et al. Improving pregnancy outcomes in humans through studies in sheep[J]. Am J Physiol Regul Integr Comp Physiol, 2018, 315(6): R1123-R1153. DOI:10.1152/ajpregu.00391.2017 .
7	杨杏, 潘兴芳, 赵天易, 等. 继发性淋巴水肿动物模型的研究进展[J]. 实验动物与比较医学, 2022, 42(1):62-67.
	YANG X, PAN X F, ZHAO T Y, et al. Progress in animal models of secondary lymphedema[J]. Lab Animal Comp Med, 2022, 42(1):62-67.
8	DANIEL-CARLIER N, HARSCOËT E, THÉPOT D, et al. Gonad differentiation in the rabbit: evidence of species-specific features[J]. PLoS One, 2013, 8(4): e60451. DOI:10.1371/journal.pone.0060451 .
9	NATURIL-ALFONSO C, MARCO-JIMÉNEZ F, JIMÉNEZ-TRIGOS E, et al. Role of embryonic and maternal genotype on prenatal survival and foetal growth in rabbit[J]. Reprod Domest Anim, 2015, 50(2):312-320. DOI:10.1111/rda.12493 .
10	VICENTE J S, LLOBAT M D, JIMÉNEZ-TRIGOS E, et al. Effect of embryonic and maternal genotype on embryo and foetal survival in rabbit[J]. Reprod Domest Anim, 2013, 48(3):402-406. DOI:10.1111/rda.12087 .
11	GONZALEZ-BULNES A, CHAVATTE-PALMER P. Contribution of large animals to translational research on prenatal programming of obesity and associated diseases[J]. Curr Pharm Biotechnol, 2017, 18(7):541-551. DOI:10.2174/1389201018666170811150920 .
12	DUNLOP K, SARR O, STACHURA N, et al. Differential and synergistic effects of low birth weight and western diet on skeletal muscle vasculature, mitochondrial lipid metabolism and insulin signaling in male Guinea pigs[J]. Nutrients, 2021, 13(12):4315. DOI:10.3390/nu13124315 .
13	BAZER F W, JOHNSON G A. Pig blastocyst-uterine inter-actions[J]. Differentiation, 2014, 87(1-2):52-65. DOI:10.1016/j.diff.2013.11.005 .
14	FERENC K, PIETRZAK P, GODLEWSKI M M, et al. Intrauterine growth retarded piglet as a model for humans: studies on the perinatal development of the gut structure and function[J]. Reprod Biol, 2014, 14(1):51-60. DOI:10.1016/j.repbio.2014.01.005 .
15	GAO H M, ZHANG L C, WANG L G, et al. Liver transcriptome profiling and functional analysis of intrauterine growth restriction (IUGR) piglets reveals a genetic correction and sexual-dimorphic gene expression during postnatal development[J]. BMC Genom, 2020, 21(1):701. DOI:10.1186/s12864-020-07094-9 .
16	BAILEY M, CHRISTOFORIDOU Z, LEWIS M C. The evolu-tionary basis for differences between the immune systems of man, mouse, pig and ruminants[J]. Vet Immunol Immuno-pathol, 2013, 152(1-2):13-19. DOI:10.1016/j.vetimm. 2012.09.022 .
17	FAVRE-INHOFER A, CARBONNEL M, DOMERT J, et al. Involving animal models in uterine transplantation[J]. Front Surg, 2022, 9:830826. DOI:10.3389/fsurg.2022.830826 .
18	CARTER A M. Evolution of placentation in cattle and antelopes[J]. Anim Reprod, 2020, 16(1):3-17. DOI:10.21451/1984-3143-AR2018-00145 .
19	MORRISON J L. Sheep models of intrauterine growth restriction: fetal adaptations and consequences[J]. Clin Exp Pharmacol Physiol, 2008, 35(7):730-743. DOI:10.1111/j.1440-1681.2008.04975.x .
20	TANNER A R, KENNEDY V C, LYNCH C S, et al. In vivo investigation of ruminant placenta function and physiology–a review[J]. J Anim Sci, 2022, 100(6): skac045. DOI:10.1093/jas/skac045 .
21	GRIGSBY P L. Animal models to study placental development and function throughout normal and dysfunctional human pregnancy[J]. Semin Reprod Med, 2016, 34(1):11-16. DOI:10.1055/s-0035-1570031 .
22	RYAN A M, BAUMAN M D. Primate models as a translational tool for understanding prenatal origins of neuro-developmental disorders associated with maternal infection[J]. Biol Psychiatry Cogn Neurosci Neuroimaging, 2022, 7(5):510-523. DOI:10.1016/j.bpsc.2022.02.012 .
23	王宏, 付学魏, 陈智岗, 等. 昆明地区恒河猴、食蟹猴种群繁殖规律和繁殖性能研究[J]. 中国比较医学杂志, 2017, 27(7):34-39. DOI:10.3969.j.issn.1671-7856.2017.07.007 .
	WANG H, FU X W, CHEN Z G, et al. Population reproductive regularity and reproductive performance of rhesus monkeys and cynomolgus monkeys in Kunming area[J]. Chin J Comp Med, 2017, 27(7):34-39. DOI:10.3969.j.issn.1671-7856.2017.07.007 .
24	BAUER C. The baboon (Papio sp.) as a model for female reproduction studies[J]. Contraception, 2015, 92(2):120-123. DOI:10.1016/j.contraception.2015.06.007 .
25	LI W, LI B, LV J Q, et al. Choline supplementation improves the lipid metabolism of intrauterine-growth-restricted pigs[J]. Asian-Australas J Anim Sci, 2018, 31(5):686-695. DOI:10.5713/ajas.15.0810 .
26	TANG X P, XIONG K N. Intrauterine growth retardation affects intestinal health of suckling piglets via altering intestinal antioxidant capacity, glucose uptake, tight junction, and immune responses[J]. Oxid Med Cell Longev, 2022, 2022:2644205. DOI:10.1155/2022/2644205 .
27	PAREDES S P, JANSMAN A J M, VERSTEGEN M W A, et al. Identifying the limitations for growth in low performing piglets from birth until 10 weeks of age[J]. Animal, 2014, 8(6):923-930. DOI:10.1017/S175173111400069X .
28	VAN GINNEKEN C, AYUSO M, VAN BOCKSTAL L, et al. Preweaning performance in intrauterine growth-restricted piglets: characteristics and interventions[J]. Mol Reprod Dev, 2022:2022 Jun 2. DOI:10.1002/mrd.23614 .
29	段畅, 王曜晖, 高静, 等. 各种宫内发育迟缓动物模型的比较[J]. 重庆医学, 2016, 45(5):696-699. DOI:10.3969/j.issn.1671-8348.2016.05.042 .
	DUAN C, WANG Y H, GAO J, et al. Comparison of various animal models of intrauterine developmental delay [J]. Chongqing Med, 2016, 45(5):696-699. DOI:10.3969/j.issn.1671-8348.2016.05.042 .
30	TAN C Q, HUANG Z H, XIONG W Y, et al. A review of the amino acid metabolism in placental function response to fetal loss and low birth weight in pigs[J]. J Anim Sci Biotechnol, 2022, 13(1):28. DOI:10.1186/s40104-022-00676-5 .
31	CHU A, THAMOTHARAN S, GANGULY A, et al. Gestational food restriction decreases placental interleukin-10 expression and markers of autophagy and endoplasmic reticulum stress in murine intrauterine growth restriction[J]. Nutr Res, 2016, 36(10):1055-1067. DOI:10.1016/j.nutres. 2016. 08.001 .
32	SELIVANOVA E K, SHVETSOVA A A, SHILOVA L D, et al. Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats[J]. Sci Rep, 2021, 11:14475.DOI:10.1038/s41598-021-93491-3 .
33	GARCIA-CONTRERAS C, VAZQUEZ-GOMEZ M, PESANTEZ-PACHECO J L, et al. Maternal metformin treatment improves developmental and metabolic traits of IUGR fetuses[J]. Biomolecules, 2019, 9(5):166. DOI:10.3390/biom9050166 .
34	PEREIRA S P, TAVARES L C, DUARTE A I, et al. Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction[J]. Clin Sci (Lond), 2021, 135(9):1103-1126. DOI:10.1042/CS20201339 .
35	SIMONCINI S, COPPOLA H, ROCCA A, et al. Endothelial colony-forming cells dysfunctions are associated with arterial hypertension in a rat model of intrauterine growth restriction[J]. Int J Mol Sci, 2021, 22(18):10159. DOI:10.3390/ijms221810159 .
36	ROBERTS V H J, GAFFNEY J E, MORGAN T K, et al. Placental adaptations in a nonhuman primate model of gestational protein restriction[J]. J Dev Orig Health Dis, 2021, 12(6):908-914. DOI:10.1017/S204017442000121X .
37	ARMENGAUD J B, YZYDORCZYK C, SIDDEEK B, et al. Intrauterine growth restriction: Clinical consequences on health and disease at adulthood[J]. Reproductive Toxicol, 2021, 99:168-176. DOI:10.1016/j.reprotox.2020.10.005 .
38	EIXARCH E, HERNANDEZ-ANDRADE E, CRISPI F, et al. Impact on fetal mortality and cardiovascular Doppler of selective ligature of uteroplacental vessels compared with undernutrition in a rabbit model of intrauterine growth restriction[J]. Placenta, 2011, 32(4):304-309. DOI:10.1016/j.placenta.2011.01.014 .
39	DUCSAY C A, MLYNARCZYK M, KAUSHAL K M, et al. Long-term hypoxia enhances ACTH response to arginine vasopressin but not corticotropin-releasing hormone in the near-term ovine fetus[J]. Am J Physiol Regul Integr Comp Physiol, 2009, 297(3): R892-R899. DOI:10.1152/ajpregu.00220. 2009 .
40	ROUSSEAU-RALLIARD D, AUBRIÈRE M C, DANIEL N, et al. Importance of windows of exposure to maternal high-fat diet and feto-placental effects: discrimination between pre-conception and gestational periods in a rabbit model[J]. Front Physiol, 2021, 12:784268. DOI:10.3389/fphys.2021.784268 .
41	LOPEZ-TELLO J, ARIAS-ALVAREZ M, GONZALEZ-BULNES A, et al. Models of Intrauterine growth restriction and fetal programming in rabbits[J]. Mol Reprod Dev, 2019, 86(12):1781-1809. DOI:10.1002/mrd.23271 .
42	ROCK C R, WHITE T A, PISCOPO B R, et al. Cardiovascular and cerebrovascular implications of growth restriction: mechanisms and potential treatments[J]. Int J Mol Sci, 2021, 22(14):7555. DOI:10.3390/ijms22147555 .
43	AIZER A, CURRIE J. The intergenerational transmission of inequality: maternal disadvantage and health at birth[J]. Science, 2014, 344(6186):856-861. DOI:10.1126/science.1251872 .
44	WU D M, HE Z, CHEN T, et al. DNA hypermethylation of acetoacetyl-CoA synthetase contributes to inhibited cholesterol supply and steroidogenesis in fetal rat adrenals under prenatal nicotine exposure[J]. Toxicology, 2016, 340:43-52. DOI:10.1016/j.tox.2016.01.002 .
45	ZHANG G H, ZHOU J, HUANG W, et al. Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats[J]. Toxicol Lett, 2018, 296:31-38. DOI:10.1016/j.toxlet.2018.07.022 .
46	FENG J H, YAN Y E, LIANG G, et al. Maternal and fetal metabonomic alterations in prenatal nicotine exposure-induced rat intrauterine growth retardation[J]. Mol Cell Endocrinol, 2014, 394(1-2):59-69. DOI:10.1016/j.mce.2014. 06.016 .
47	MORALES-PRIETO D M, FUENTES-ZACARÍAS P, MURRIETA-COXCA J M, et al. Smoking for two-effects of tobacco consumption on placenta[J]. Mol Aspects Med, 2022, 87:101023. DOI:10.1016/j.mam.2021.101023 .
48	COLL T A, CHAUFAN G, PÉREZ-TITO L G, et al. Cellular and molecular oxidative stress-related effects in uterine myometrial and trophoblast-decidual tissues after perigestational alcohol intake up to early mouse organogenesis[J]. Mol Cell Biochem, 2018, 440(1):89-104. DOI:10.1007/s11010-017-3158-y .
49	LI Y, YAN Y E, WANG H. Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure[J]. Environ Toxicol Pharmacol, 2011, 32(3):465-471. DOI:10.1016/j.etap.2011.08.013 .
50	GHADHANFAR E, ALSALEM A, AL-KANDARI S, et al. The role of ACE2, angiotensin-(1-7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction[J]. Reprod Biol Endocrinol, 2017, 15(1):97. DOI:10.1186/s12958-017-0316-8 .
51	HUNG T H, LIU Y C, WU C H, et al. Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone-induced intrauterine growth restriction[J]. Brain Pathol, 2021, 31(6): e12968. DOI:10.1111/bpa.12968 .
52	CUFFE J S M, SAIF Z, PERKINS A V, et al. Dexamethasone and sex regulate placental glucocorticoid receptor isoforms in mice[J]. J Endocrinol, 2017, 234(2):89-100. DOI:10.1530/JOE-17-0171 .
53	ARIAS A, SCHANDER J A, BARIANI M V, et al. Dexamethasone-induced intrauterine growth restriction modulates expression of placental vascular growth factors and fetal and placental growth[J]. Mol Hum Reprod, 2021, 27(3): gaab006. DOI:10.1093/molehr/gaab006 .
54	SHALOM-PAZ E, WEILL S, GINZBERG Y, et al. IUGR induced by maternal chronic inflammation: long-term effect on offspring's ovaries in rat model—a preliminary report[J]. J Endocrinol Invest, 2017, 40(10):1125-1131. DOI:10.1007/s40618-017-0681-3 .
55	CADARET C N, MERRICK E M, BARNES T L, et al. Sustained maternal inflammation during the early third-trimester yields intrauterine growth restriction, impaired skeletal muscle glucose metabolism, and diminished β-cell function in fetal sheep 1,2[J]. J Anim Sci, 2019, 97(12):4822-4833. DOI:10.1093/jas/skz321 .
56	WANG B, XU S, LU X, et al. Reactive oxygen species-mediated cellular genotoxic stress is involved in 1-nitropyrene-induced trophoblast cycle arrest and fetal growth restriction[J]. Environ Pollut, 2020, 260:113984. DOI:10.1016/j.envpol.2020.113984 .
57	LI R, WANG X L, WANG B, et al. Gestational 1-nitropyrene exposure causes gender-specific impairments on postnatal growth and neurobehavioral development in mice[J]. Ecotoxicol Environ Saf, 2019, 180:123-129. DOI:10.1016/j.ecoenv.2019.05.016 .
58	GUO C, YANG Y, SHI M X, et al. Critical time window of fenvalerate-induced fetal intrauterine growth restriction in mice[J]. Ecotoxicol Environ Saf, 2019, 172:186-193. DOI:10.1016/j.ecoenv.2019.01.054 .
59	RUFF C A, FAULKNER S D, RUMAJOGEE P, et al. The extent of intrauterine growth restriction determines the severity of cerebral injury and neurobehavioural deficits in rodents[J]. PLoS One, 2017, 12(9): e0184653. DOI:10.1371/journal.pone. 0184653 .
60	SUTHERLAND A E, YAWNO T, CASTILLO-MELENDEZ M, et al. Does antenatal betamethasone alter white matter brain development in growth restricted fetal sheep? [J]. Front Cell Neurosci, 2020, 14:100. DOI:10.3389/fncel.2020.00100 .
61	EIXARCH E, FIGUERAS F, HERNÁNDEZ-ANDRADE E, et al. An experimental model of fetal growth restriction based on selective ligature of uteroplacental vessels in the pregnant rabbit[J]. Fetal Diagn Ther, 2009, 26(4):203-211. DOI:10.1159/000264063 .
62	CAMPRUBÍ M, ORTEGA Á, BALAGUER A, et al. Cauterization of meso-ovarian vessels, a new model of intrauterine growth restriction in rats[J]. Placenta, 2009, 30(9):761-766. DOI:10.1016/j.placenta.2009.06.010 .
63	COATS L E, BAKRANIA B A, BAMRICK-FERNANDEZ D R, et al. Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric intrauterine growth restriction or cardiovascular risk induced by placental ischemia in the rat[J]. Am J Physiol Heart Circ Physiol, 2021, 320(5): H1923-H1934. DOI:10.1152/ajpheart.00033.2021 .
64	LIN C, HE H, CUI N, et al. Decreased uterine vascularization and uterine arterial expansive remodeling with reduced matrix metalloproteinase-2 and-9 in hypertensive pregnancy[J]. Am J Physiol Heart Circ Physiol, 2020, 318(1): H165-H180. DOI:10.1152/ajpheart.00602.2019 .
65	COATS L E, BAMRICK-FERNANDEZ D R, ARIATTI A M, et al. Stimulation of soluble guanylate cyclase diminishes intrauterine growth restriction in a rat model of placental ischemia[J]. Am J Physiol Regul Integr Comp Physiol, 2021, 320(2): R149-R161. DOI:10.1152/ajpregu.00234.2020 .
66	SEKIMOTO A, TANAKA K, HASHIZUME Y, et al. Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice[J]. Biochem Biophys Res Commun, 2020, 521(3):769-774. DOI:10.1016/j.bbrc.2019.10.186 .
67	TRAVIS O K, BAIK C, TARDO G A, et al. Adoptive transfer of placental ischemia-stimulated natural killer cells causes a preeclampsia-like phenotype in pregnant rats[J]. Am J Reprod Immunol, 2021, 85(6): e13386. DOI:10.1111/aji.13386 .
68	GILBERT J S, BAUER A J, GINGERY A, et al. Circulating and utero-placental adaptations to chronic placental ischemia in the rat[J]. Placenta, 2012, 33(2):100-105. DOI:10.1016/j.placenta.2011.11.025 .
69	MCARDLE A M, ROBERTS C T, MADUWEGEDERA D, et al. Chronic maternal hypertension characterized by renal dysfunction is associated with reduced placental blood flow during late gestation in rabbits[J]. Am J Physiol Regul Integr Comp Physiol, 2010, 298(4): R1043-R1049. DOI:10.1152/ajpregu. 00202.2009 .
70	BEUNE I M, BLOOMFIELD F H, GANZEVOORT W, et al. Consensus based definition of growth restriction in the newborn[J]. J Pediatr, 2018, 196:71-76.e1. DOI:10.1016/j.jpeds.2017.12.059 .
71	LAI J, SYNGELAKI A, NICOLAIDES K H, et al. Using ultrasound and angiogenic markers from a 19- to 23-week assessment to inform the subsequent diagnosis of preeclampsia[J]. Am J Obstet Gynecol, 2022, 227(2):294.e1-294.e11. DOI:10.1016/j.ajog.2022.03.007 .

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胎儿宫内生长受限动物模型的研究进展

Research Progress on Animal Models of Intrauterine Growth Restriction

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