关键词: 低剂量铅暴露, 神经行为, 损伤, 仔鼠

Abstract: Objective To discuss whether the filial generation rats could be injured in neural behaviour development from low dose of lead acetate which were exposed to the parent rat during its pregnancy. Methods: At the first day of the pregnancy, the rats were divided into five groups, the first and second group are early pregnancy rats with l00mg·kg^-1-d^-1 and 1000 mg·kg^-1-d^-1 lead acetate by gavage at 10 ml·kg^-1,total exposure 42 days, the third and fourth group are late pregnancy rat with 100 mg·kg^-1. d^-1 and 1000 mg·kg^-1·d^-1 lead acetate, total exposure 28 days and the control group with distilled water.The offspring rats of each groups were tested for surface righting,cliff avoidance and slop turning at 5th day after birth，for body righting reflex and forelimb handgrip at 10th day. Result The offspring rats of four doses group have observably effects in early nervous reflex and locomotives, increasing with the exposure dosage and time. Conclusion Lead acetate affects offspring’s early nervous reflex and early locomotives through the placenta and milk.

Key words: Lead exposure, Nervous reflex and locomotives, Injury, offspring