关键词: 实验动物, 猕猴, 比格犬, 树鼩, 兔, 大鼠, 小鼠, 消化腺, 比较组织学

Abstract: Objective To study the histological differences on digestive glands among 6 species of laboratory animals, and observe their spontaneous lesions, providing a theoretical basis for pathological testing standards of laboratory animals. Methods 30 rhesus monkeys, 16 Beagle dogs, 18 Japanese white rabbits, 20 SD rats and 20 KM mice for study. The same and different histological structure characters of them were summarized by comparative study, spontaneous lesions of digestive gland were observed. Results (1) The major histological differences of parotid gland, submandibular gland and sublingual gland were acinar structures, adipose tissue content in acinus, AB/PAS staining status of glutinous acinus and the histological structures of conduct pipe. (2)Beagle dog had a couple of glandula zygomaticas, and Japanese rabbit had a couple of suborbital glands as a exclusive salivary gland.(3)The major histological differences of liver were the histological structures of hepatic lobule and portal area, morphological characters of hepatocytes. (4)Whether the presence of lymphoid tissue in glandular lobule and the histological structures of conduct pipe were major histological differences of pancreas. (5)Whether the presence of mucous membrane antrums and the morphological characters of germinal epithelium were major histological differences of gallbladder.(6) Inflammation was a common spontaneous lesions of liver. Conclusion Some valuable digestive gland histological data in 6 species of laboratony animals were obtained, and their different histology characters were revealed. The histological differences on digestive glands and spontaneous lesions in different animal species should be fully considered in biomedical researches.

Key words: Laboratory animals, Rhesus monkey, Beagle dog, Japanese white rabbit, Tree shrew, SD rat, KM mouse, Digestive gland, Comparative histology