实验动物与比较医学 ›› 2022, Vol. 42 ›› Issue (2): 166-170.DOI: 10.12300/j.issn.1674-5817.2021.078

所属专题: 实验动物伦理与福利专辑

• 实验动物福利与伦理 • 上一篇    

电极植入猕猴脑皮层手术的护理实践及探讨

徐西彬(), 朱青, 张恩()   

  1. 北京师范大学认知神经科学与学习国家重点实验室, 北京 100875
  • 收稿日期:2021-04-07 修回日期:2021-09-23 出版日期:2022-04-25 发布日期:2022-05-07
  • 通讯作者: 张 恩(1979—),男,博士,讲师,研究方向:视知觉与知觉学习的神经机制。E-mail: ZhangEn@bnu.edu.cn
  • 作者简介:徐西彬(1978—),男,硕士,实验师,研究方向:神经生物学。E-mail: xuxibin2004@bnu.edu.cn
  • 基金资助:
    国家自然科学基金资助项目: 视觉信息的多重表征及其经验依赖性(31771203)

Nursing Practice and Discussion of Electrode Implantation into Cerebral Cortex of Rhesus Monkey

Xibin XU(), Qing ZHU, En ZHANG()   

  1. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
  • Received:2021-04-07 Revised:2021-09-23 Online:2022-04-25 Published:2022-05-07
  • Contact: ZHAGN En, E-mail: ZhangEn@bnu.edu.cn

摘要:

利用电极植入技术探讨群体神经元的电活动对于脑与认知科学、类脑研究和脑机接口技术研究是至关重要的。本文介绍了电极植入猕猴大脑皮层手术前、中、后的护理要点及其重要意义。其中,术前护理包括术前准备、术前用药和头颅固定、备皮等,术中护理包括生理指标监护和脑皮层植入手术护理,术后护理包括观察监测、清创和营养护理。做好电极植入猕猴脑皮层手术的护理,不仅能够提高手术成功率,使用尽量少的实验动物来获取实验所需数据,而且能够减轻手术给动物带来的疼痛和伤害,对脑与认知科学研究和保障动物福利均具有重要意义。

关键词: 电极植入, 脑皮层手术, 护理, 实验动物福利, 猕猴

Abstract:

The use of electrode implantation technology to explore the electrical activity of population neurons is crucial for brain and cognitive science, brain-like research and brain-computer interface technology research. This article introduces the nursing points and significance of electrode implantation in rhesus monkey cerebral cortex before, during and after operation. Preoperative care includes preoperative preparation, preoperative medication, cranial fixation, skin preparation, etc. Intraoperative care includes physiological index monitoring and cerebral cortex implantation surgery care, while postoperative care includes observation and monitoring, debridement and nutritional care. Doing a good job in the operation of electrode implantation into the cerebral cortex of rhesus monkeys can not only improve the success rate of the operation, use as few experimental animals as possible to obtain the data required for the experiment, but also reduce the pain and injury caused by the operation to the animals, which is of great significance for brain and cognitive science research and animal welfare protection.

Key words: Electrode implantation, Cortical surgery, Nursing, Laboratory animal welfare, Rhesus monkeys

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