关键词: 品系, 小鼠, 血管再狭窄, 血管再构, 新内膜形成

Abstract: Restenosis is one of the major limitations of PTCA and CABG, it can be as-sumed as a combination of neointima formation and arterial remodeling in response to in-jury. We rcccnlly established model with mice BALB/cA and C57BL/6J. After ligation of the left common carotid artery just proximal to the bifurcation resulting in 90% re-duction of lumen area by a combination of intimal hyperplasia together with decreased diameter. In this study, neointima formation in C57BL/6J micc and BALB/cA mice was compared. Two and four weeks after the ligation, lcukocyte infiltration was observed in the developing neointima, a 90% reduction of luminal area was observed in C57BL/6J ； While in BALB/cA no neointima formation was observed. Conclusion : Vascular remod-eling with neointima formation was the cause of restenosis, presumably by mediating leukocyte recruitment and the interaction between platelets and leukocytes.

Key words: Restenosis , Remodeling , Neointima formation