实验动物与比较医学 ›› 2026, Vol. 46 ›› Issue (2): 279-287.DOI: 10.12300/j.issn.1674-5817.2025.101

• 教学培训实践 • 上一篇    下一篇

微创外科教育培训中实验动物使用的现状分析与替代技术探索

刘意抒1(), 蔡丽萍2()()   

  1. 1.海军军医大学第三附属医院内科学与野战内科学教研室, 上海 200438
    2.海军军医大学第一附属医院临床教育中心, 上海 200433
  • 收稿日期:2025-07-01 修回日期:2025-10-07 出版日期:2026-04-25 发布日期:2026-04-18
  • 通讯作者: 蔡丽萍(1983—),女,硕士,主管技师,研究方向:实验动物应用研究、医学模拟教育。E-mail: ccg9115@126.com。ORCID: 0009-0003-5485-5506
  • 作者简介:刘意抒(1988—),女,硕士,副教授,研究方向:医学模拟教育、院校教育。E-mail: yishu1128@163.com。ORCID: 0009-0002-2989-4557
  • 基金资助:
    教育部产学合作协同育人项目“虚拟现实技术在腹腔镜手术培训中的应用研究”(241005236213411);海军军医大学“深蓝”人才工程“启航”人才项目

Analysis of Current Practices and Exploration of Alternative Technologies in Use of Laboratory Animals for Minimally Invasive Surgery Education and Training

LIU Yishu1(), CAI Liping2()()   

  1. 1.Department of Internal Medicine and Field Internal Medicine, The Third Affiliated Hospital of Naval Medical University, Shanghai 200438, China
    2.Clinical Education Center, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
  • Received:2025-07-01 Revised:2025-10-07 Published:2026-04-25 Online:2026-04-18
  • Contact: CAI Liping (ORCID: 0009-0003-5485-5506), E-mail: ccg9115@126.com

摘要:

当前,微创外科技术的迅猛发展对传统外科教育培训体系提出了严峻挑战,依赖实验动物的教学模式因伦理争议、成本高昂及模型局限性等问题面临转型需求。通过系统文献分析与海军军医大学第一附属医院达芬奇手术机器人培训中心的实践经验总结相结合的模式,本研究系统评估了实验动物在达芬奇机器人操作系统及腹腔镜教育培训中的多维效能。结果表明,在现有的技术条件下,实验动物凭借其真实的组织触觉反馈、动态生理响应特性及复杂术野暴露训练优势,仍是高阶手术技能培养(如血管解剖游离、器官缝合等)的核心载体,其不可替代性主要体现在术中动态生理响应模拟和紧急状况处置训练等关键教学环节。基于跨学科视角的技术评估与实践观察,笔者提出并构建了“伦理-技术协同”发展框架,并深入探讨了扩展现实(extended reality)技术的虚实融合交互机制、类器官模型的病理模拟平台构建以及数字共享平台的资源协调机制的创新价值。结合培训中心的应用案例,验证了这些技术构成“阶梯式替代”实验动物路径的潜力,并揭示了其在标准化场景复现、触觉模拟精度提升及减少实验动物使用量方面的关键突破。本研究强调,微创外科教育培训体系的变革不仅是技术创新,更是伦理观念的升级,基于伦理-技术协同的路径需重点聚焦技术整合维度构建多模态混合训练系统、资源管理维度建立生物样本协同共享网络、伦理实践维度完善动物使用必要性评估标准3大实施方向,从而为构建兼顾技术效能与伦理合规的新型培训范式体系,提供可操作的实践路径,推动外科教育向精准化、无害化转型。

关键词: 达芬奇机器人操作系统, 腹腔镜培训, 实验动物, 虚拟现实, 微创外科教育, 伦理-技术协同

Abstract:

Currently, the rapid development of minimally invasive surgical techniques poses significant challenges to the traditional surgical education and training system. The teaching model relying on laboratory animals is facing the need for transformation due to ethical controversies, high costs, and limitations of the model. Through a combined approach of systematic literature analysis and summarization of practical experience at the Da Vinci Surgical Robot Training Center at the First Affiliated Hospital of Naval Medical University, this study systematically evaluated the multidimensional efficacy of laboratory animals in training for the Da Vinci robot operating system and laparoscopic techniques. The results indicate that, under current technological conditions, laboratory animals—leveraging their advantages of authentic tissue tactile feedback, dynamic physiological responses, and the ability to be trained under complex surgical field exposure—remain the core modality for cultivating advanced surgical skills (such as vascular dissection and mobilization, organ suturing, etc.). Their irreplaceability lies primarily in key training aspects such as simulating intraoperative dynamic physiological responses and handling intraoperative emergencies. Based on interdisciplinary technical assessment and practical observation, the authors propose and construct an "Ethics-Technology Synergy" development framework. They further explore the innovative value of the virtual-real interaction mechanism in extended reality technology, the construction of pathological simulation platforms using organoid models, and the resource coordination mechanism of digital sharing platforms. Using application cases from the training center, the study verifies the potential of these technologies to form a "stepwise replacement" pathway for laboratory animals. It also highlights their key breakthroughs in standardized scenario replication, improved tactile simulation accuracy, and reduced laboratory animal usage. This study emphasizes that the transformation of the minimally invasive surgical education and training system is not only a technological innovation but also an advancement of ethical concepts. The "Ethics-Technology Synergy" pathway requires focusing on three key implementation areas: constructing a multi-modal hybrid training system from the perspective of technological integration; establishing a collaborative biological specimen sharing network from the perspective of resource management; and refining standards for assessing the necessity of animal use from the perspective of ethical practice. This provides an actionable pathway for building a new training paradigm that balances technical efficacy with ethical compliance, thereby promoting the transformation of surgical education towards precision and minimal harm.

Key words: Da Vinci robot operating system, Laparoscopic training, Laboratory animal, Virtual reality, Minimally invasive surgery education, Ethics-technology synergy

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