图1 小鼠肝组织HE染色结果（×40）及血清谷丙转氨酶和谷草转氨酶水平注：A为对照组和模型组小鼠肝组织HE染色结果，蓝色箭头指示肝细胞中的脂滴空泡，黑色箭头指示被挤压至边缘的细胞核；B为用紫外微孔板法检测的两组小鼠血清中的谷丙转氨酶（ALT）和谷草转氨酶（AST）水平。每组6只小鼠；与对照组比较，??P＜0.01。

Figure 1 HE staining results of liver tissue （×40） and serum ALT and AST levels in miceNote： A shows HE staining images of liver tissue in control and model group mice， the blue arrows indicate the hepatocytes with macrovesicular fat， and the black arrow indicates the nuclei pushed to the edge. B shows the alanine aminotransferase（ALT） and aspartate aminotransferase（AST） levels in the two groups detected by ultraviolet microplate method. n = 6；Compared with the control group，??P＜0.01.

图2 小鼠胃黏膜表面pCLE图像（×1 000）和胃组织HE染色图（×20）注：对照组小鼠胃黏膜表面探头式激光共聚焦成像图中，红色虚线圈指示胃小凹，蓝色箭头指示胃小凹边界；模型组小鼠胃黏膜表面探头式激光共聚焦成像图中，黄色虚线圈指示肿胀变形的胃小凹，红色箭头指示胃黏膜表面脱落的组织细胞碎片。对照组小鼠胃组织HE染色图中，黑色箭头指示排列整齐的腺管；模型组小鼠胃组织HE染色图中，红色星号指示胃组织水肿区域。

Figure 2 pCLE images of gastric mucosa surface （×1 000） and HE staining images of gastric tissue （×20） in miceNote： In probe-based confocal laser endomicroscopy（pCLE） images of the gastric mucosa surface， red dashed circle indicates gastric foveae and blue arrows indicate the border of the gastric foveae in the control group， yellow dashed circle shows swollen and deformed gastric foveae and the red arrows are detached tissue cell fragments on the gastric mucosa surface in the model group. In HE staining images of gastric tissues， black arrows indicate neatly arranged glandular ducts in the control group and the red asterisks indicate edematous areas of gastric tissues in the model group.

图3 小鼠十二指肠黏膜表面pCLE图像（×1 000）和十二指肠组织HE染色图（×20）注：小鼠十二指肠黏膜表面探头式激光共聚焦成像图中，蓝色箭头为清晰的十二指肠边界，红色箭头为十二指肠黏膜脱落的组织细胞碎片，黄色星号为荧光素渗漏的亮色区域；小鼠十二指肠HE染色图中，黑色箭头所示为炎性细胞浸润，红色星号为肠绒毛水肿，黑色星号为肠绒毛坏死脱落。

Figure 3 pCLE images of duodenal mucosa surface （×1 000） and HE staining images of duodenal tissue （×20） in miceNote： In probe-based confocal laser endomicroscopy（pCLE）images of the duodenal mucosa surface in mice， blue arrow indicates a clear duodenal mucosal boundary， red arrows indicate detached tissue cell fragments on the duodenal mucosa surface， yellow asterisks indicate bright areas of fluorescein leakage. In HE staining images of mouse duodenal tissues， black arrows indicate inflammatory cell infiltration， red asterisk indicates intestinal villi edema and black asterisk indicates intestinal villi necrosis and shedding.

图4 小鼠空肠黏膜表面pCLE图像（×1 000）和小鼠空肠组织HE染色图（×20）注：模型组小鼠空肠黏膜表面探头式激光共聚焦成像图中，红色箭头为空肠黏膜表面组织细胞点灶状坏死区，黄色星号为荧光素渗漏的局部亮色区域；模型组小鼠空肠HE染色图中，黑色箭头所示为形态结构被破坏的肠绒毛，顶端断裂、脱落，红色虚线圈为拥挤的腺体。

Figure 4 pCLE images of jejunum mucosa surface （×1 000） and HE staining images of jejunum tissue （×20） in miceNote： In probe-based confocal laser endomicroscopy（pCLE）images of the jejunum mucosa surface in the model group， red arrows indicate focal necrosis area of surface tissue cells in the jejunum mucosa， and yellow asterisks show local bright area of fluorescein leakage. In HE staining images of jejunal tissues in the model group， black arrows indicate the intestinal villi with destroyed morphological structure， exhibiting apical rupture and shedding， and red dashed circle indicates crowded glands.

图5 小鼠直肠黏膜表面pCLE图像（×1 000）和小鼠直肠组织HE染色图（×10）注：对照组小鼠直肠黏膜表面探头式激光共聚焦成像图中，红色虚线圈指示直肠隐窝，蓝色箭头指示清晰的直肠隐窝边界；模型组小鼠直肠黏膜表面激光共聚焦图像中，黄色虚线圈指示相邻隐窝融合，红色箭头指示直肠黏膜表面组织细胞脱落处；模型组小鼠直肠组织HE染色图中，黑色箭头指示腺管排列紊乱，红色星号指示上皮结构不完整。

Figure 5 pCLE images of rectal mucosa surface （×1 000） and HE staining images of rectal tissue （×10） in miceNote： In probe-based confocal laser endomicroscopy（pCLE）images of the rectal mucosa surface， red dashed circle indicates rectal crypts and blue arrow indicates clear rectal crypts boundary in the control group， yellow dashed circle shows fusion of adjacent crypts， and red arrows indicate tissue cells exfoliation on the rectal mucosa surface in the model group. In HE staining images of rectal tissues in the model group， black arrows indicate disordered arrangement of glandular ducts and red asterisks indicate that the intestinal epithelial structure is incomplete.