猴巨细胞病毒研究进展

doi:10.3969/j.issn.1674-5817.2014.03.016

摘要/Abstract

摘要： 猴巨细胞病毒(Simian Cytomegalovirus,SCMV)在生物学分类上属于疱疹病毒beta亚型,是一群有囊膜的DNA病毒,与疱疹病毒拥有相似的结构特点,而且能引起持续的隐性感染。目前SCMV作为最合适的人类巨细胞病毒(HCMV)研究模型被广为关注,探究其感染途径、致病机理、诊疗方法等研究将为HCMV的研究打下基础。本文就SCMV的发现与分类、生物学特性及感染特征与免疫应答、检测方法、疫苗研究以及发展前景做一综述,以期为研究者提供一些有用参考。

关键词: 猴巨细胞病毒(SCMV), 特性, 检测, 疫苗

Abstract: Simian cytomegalovirus(SCMV) were the prototypic members of the beta herpesvirus subgroup, a group of DNA virus with segment rounded. Like all herpesvirus, they shared the similar structure characteristics, and could initiate persistent latent infection. Recently, SCMV were wildly concerned as the best suited model for human cytomegalovirus (HCMV) research, and the study of infection route, pathogenic mechanism and diagnosis and treatment for SCMV could lay a foundation for those of HCMV. This article reviewed the discovery , classification, biological characteristics, infection characteristics and immunological response, detections of SCMV, vaccines reserch and development prospects so as to provide some useful insights for researchers.

Key words: Simian Cytomegalovirus, Biological characteristics, Detection, Vaccines

中图分类号:

Q95-33

王莎莎, 贺争鸣. 猴巨细胞病毒研究进展[J]. 实验动物与比较医学, 2014, 34(3): 242-248.

WANG Sha-sha, HE Zheng-ming. The Research Progress on Simian Cytomegalovirus[J]. Laboratory Animal and Comparative Medicine, 2014, 34(3): 242-248.

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