甲状腺疾病啮齿类动物模型的研究进展

doi:10.3969/j.issn.1674-5817.2017.02.015

摘要/Abstract

摘要： 综述了甲状腺功能亢进症、甲状腺功能减退症、自身免疫性甲状腺炎和甲状腺癌等甲状腺疾病啮齿类动物模型的建立方法,并对分化型甲状腺癌术后促甲状腺激素(TSH)抑制治疗大鼠模型的建立提出设想。

Abstract: This paper summarized the methods for establishing the rodent model of hyperthyroidism, hypothyroidism, autoimmune thyroiditis and thyroid carcinoma, and proposed a method for establishing the rat model of thyroid-stimulating hormone (TSH) suppression therapy for post-operation differentiated thyroid carcinoma.

Key words: Thyroid diseases, Rodent model, Animal experiment

中图分类号:

Q95-33

塔拉, 金山. 甲状腺疾病啮齿类动物模型的研究进展[J]. 实验动物与比较医学, 2017, 37(2): 160-165.

TA La, JIN Shan. Establishment of Rodent Model of Thyroid Diseases[J]. Laboratory Animal and Comparative Medicine, 2017, 37(2): 160-165.

参考文献

[1] 滕卫平, 邢小平, 童南伟, 等. 中国十城市甲状腺疾病流行病学调查结果[EB/OL]. http://yy.chinairn, com/news/20141024/114826833, 2014-10-24.
[2] Durante C, Costante G, Filetti S.Differentiated thyroid carcinoma:defining new paradigms for postoperative management[J]. Endocr Relat Cancer, 2013, 20(4):141-154.
[3] 丛舒, 方利文, 包鹤龄, 等. 1990年与2013年中国人群甲状腺癌疾病负担分析[J]. 中华流行病学杂志, 2016, 37(6): 773-777.
[4] Sanjadian M, Hashemi M, Salimi S, et al.The effect of experimental thyroid dysfunction on markers of oxidative stress in rat pancreas[J]. Drug Dev Res, 2016, 77(4):199-205.
[5] Gunasekera RD, Kuriyama H.The influence of thyroid states upon responses of the rat aorta to catecholamines[J]. Br J Pharmacol, 1990, 99(3):541-547.
[6] Park SI, Lee YJ, Choi SH, et al.Therapeutic effects of blue honeysuckle on lesions of hyperthyroidism in rats[J]. Am J Chin Med, 2016, 44(7):1441-1456.
[7] Sajadian M, Hashemi M, Salimi S, et al.The effect of experiment thyroid dysfunction on markers of oxidative stress in rat pancreas[J].Drug Dev Res, 2016, 77(4):199-205.
[8] Donzelli R, Colligiani D, Kusmic C, et al.Effect of hypothyroidism and hyperthyroidism on tissue thyroid hormone concentrations in rat[J]. Eur Thyroid J, 2016, 5(1):27-34.
[9] Shimojo N, Kohno Y, Yamaguchi K, et al.Induction of graves-like disease in mice by immunization with fibroblasts trans-fected with the thyrotropin receptor and a class Ⅱ molecule[J]. Proc Natl Acad Sci USA, 1996, 93(20):11074-11079.
[10] Ando T, Imaizumi M, Graves P, et al.Induction of thyroid-stimulating hormone receptor autoimmunity in hamsters[J].Endocrinology, 2003, 144(2):671-680.
[11] Kaithamana S, Fan J, Osuga Y, et al.Induction of experimental autoimmune Graves'disease in BALB/c mice[J]. J Immunol,1999, 163(9):5157-5164.
[12] Nagayama Y,Kita-Furuyama M,Ando T, et al.A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor[J]. J Immunol, 2002, 168(6):2789-2794.
[13] Endo T, Kobayashi T.Immunization with thyroglobulin induces Graves'like disease in mice[J]. Endocrinol, 2009, 202(2):217-222.
[14] Demir, Ünübol M, Aypak SÜ, et al. Histopathologic evaluation of nonalcoholic fatty liver disease in hypothyroidism-induced rats[J/OL]. Int J Endocrinol, 2016, doi:10.1155/2016/5083746.
[15] Shahrivar FF, Badavi M, Dianat M, et al.Exogenous apelin changes alpha and beta myosin heavy chain mRNA expression and improves cardiac function in PTU-induced hypothyroid rats[J]. Gene, 2016, doi:10.1016/j.gene. 2016.09.025.[Epub ahead of print]
[16] Özgür E, Gürbüz Özgür B, Aksu H, et al.The effect of congenital and postnatal hypothyroidism on depression like behavior in juvenile rats[J]. J Clin Res Pediatr Endocrinol, 2016, doi:10.4274/jcrpe.3498.[Epub ahead of print]
[17] Danilovi Lukovi J, Kora A, Milo evi I, et al. Altered state of primordial follicles in neonatal and early infantile rats due to maternal hypothyroidism: Light and electron microscopy approach[J]. Micron, 2016, 90:33-42.
[18] Pergialiotis V, Agrogiannis G, Gkioka E, et al.Mammary gland epithelial changes in thyroidectomized female rats[J]. J BUON,2015, 20(1):57-61.
[19] Zhang Q, Feng JJ, Yang S, et al.Lateral habenula as a link between thyroid and serotoninergic system mediates depressive symptoms in hypothyroidism rats[J]. Brain Res Bull,2016, 124:198-205.
[20] da Conceicăo RR, Laureano-Melo R, Oliveira KC, et al.Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism[J]. Physiol Behav, 2016, 157:158-164.
[21] Maloof F, Dobyns BM, Vickery AL.The effects of various doses of radioactive iodine on the function and structure of the thyroid of the rat[J]. Endocrinology, 1952, 50(6):612-638.
[22] 崇巍, 陈威, 滕卫平, 等. 缺碘性甲状腺肿动物模型的建立及评价[J]. 中国医科大学学报, 2005, 34(2):111-113.
[23] Rabeler R, Mittag J, Geffers L, et al.Generation of thyrotropin-releasing hormone receptor 1-deficientmice as an animal model of central hypothyroidism[J]. Mol Endocrinol, 2014,18(6):1450-1460.
[24] H Xue, W Wang, Z Shan, et al.Changes of CD4+CD25+ regulatory T cells in NOD. H-2h4 mice with iodine-induced autoimmune thyroiditis[J]. Biol Trace Elem Res, 2011, 143(1):292-301.
[25] Kanistras I, Hatzioannou A, Lymberi P.A novel pathogenic peptide of thyroglobulin (2208-2227) induces autoreactive T-cell and Bcellresponses in both high and low responder mouse strains[J]. Immunology, 2014, 142(2):300-306.
[26] Cui SL, Yu J, Shoujun L.Iodine intake increases IP-10 expres sion in the serum and thyroids of rats with experimental autoimmune thyroiditis[J/OL]. Int J Endocrinol, 2014, doi:10.1155/2014/581069.
[27] Hong SH, Braley-Mullen H.Follicular B cells in thyroids of mice with spontaneous autoimmune thyroiditis contribute to disease pathogenesis and are targets of anti-CD20 antibody therapy[J]. J Immunol, 2014, 192(3):897-905.
[28] Israel MS, Ellis RI.The neoplastic potentialities of mouse thyroid under extreme stimulation[J]. Br J Cancer, 1996, 14(6):206-211.
[29] Fang WT, Qiao BS, Wang JB.Iodine deficiency induces thyroid cancer in rats and mice[J]. Chin J Oncol, 1994, 16(5):341-344.
[30] Nehs MA, Nucera C, Nagarkatti SS, et al.Late intervention with anti-BRAF(V600E) therapy induces tumor regression in an orthotopic mouse model of human anaplastic thyroid cancer[J]. Endocrinology, 2012, 153(2):985-994.
[31] Kim S, Park YW, Schiff BA, et al.An orthotopic model of anaplastic thyroid carcinoma in athymic nude mice[J]. Clin Cancer Res, 2005, 11(5):1713-1721.
[32] Biondi B,Cooper DS.The clinical significance of subclinical thyroid dysfunction[J]. Endocr Rev, 2008, 29(1):76-131.
[33] Biondi B, Cooper DS.Benefits of thyrotropin suppression versus the risk of adverse effects in differentiated thyroid cancer[J]. Thyroid, 2010, 20(2):135-146.