关键词: 大鼠, 烫伤, 创面愈合

Abstract: To explore the mechanisms in wound-healing of deep partial thickness burns of skin, an animal model was prepared by scalding SD rat skin with water at 80℃ for 6 and 15 seconds in group 1 and 2 respectively，and then followed by light microscopic ob-servation on the natural healing of the wound at fixed intervals. The local microcircula-tory impairement of the rats in group 1 was found less serious,7 days after the scald proliferation of the epithelium of hair follicles,which remained deep in the corium，took place and covering the wound surfaces, and 14 days after the scald the wounds were almost healed. In group 2，the microcirculatory impairement was so obvious.Seven 7 days after scald the wound showedwere deepening progressively from deep partial to full thickness burns,another week later abscess formed beneath the scabs that hindered the wound from healing.It is concluded that the degree of impairement of microcirculation is highly correlated with the length of time of scalding. The severity of microcirculatory impairement and the inflammatory reaction beneath the scabs are both major factors that affect the wound healing.

Key words: Rats, Scald, Burns, Wound healing