›› 1995, Vol. 15 ›› Issue (2): 79-81.

• 论文 • 上一篇    下一篇

溶脲脲原体人工感染引发大鼠膀胱结石

  

  1. 上海第二医科大学
  • 收稿日期:1994-10-17 出版日期:1995-01-25 发布日期:2013-03-19

Calculus of Rat Bladder Induced by Ureaplasma Urealyticum Inoculation

  1. Histology and Embryology department, Shanghai Second Medical University, Shanghai 200025
  • Received:1994-10-17 Online:1995-01-25 Published:2013-03-19

摘要: 100只2.5月龄清洁级SD雄性大鼠分为3组:A组45只,B组22只,C组33只。A组大鼠膀胱内注入血清8型溶脲脲原体菌株T960;B组除与A组同样处理外,且在接种后3个月给予美满霉素(20~100mg/kg),连续14d;C组为对照组,每只动物给予等量溶脲脲原体液体培养基。结果:A组87.5%、B组20%的动物膀胱组织的溶脲脲原体培养阳性,C组为阴性;A、B两组有极显著差异(P<0.001),表明美满霉素能有效地抑制溶脲脲原体。A组膀胱结石检出率为40%,B组为35%,C组为零;A、B两组无明显差异(P>0.1)。

关键词: 溶脲脲原体, 膀胱结石, 美满霉素, 大鼠

Abstract: One hundred SD male rats were randomly divided into 3 groups: group A, 45 rats, ureaplasma urealyticum (u. u. ) were inoculated into the bladders; group B, 22 rats, in addition to the inoculation of u. u., minomycin(20-100 mg/kg.day) was administrated for 14 days 3 months after the inoculation; group C, 33 rats as the control. The results showed that (1) the u. u. infective rates were 87.5%, 20% and 0% for group A, B and C respectively (P<0,001, group A versus group B); (2) the incidences of bladder calculus were 40%, 35% and 0% for group A, C respectively (P>0.1, group A versus B). The possible relationship between bladder calculus and u. u. infection was discussed.

Key words: "Ureaplasma urealyticum, Bladder calculus, Minomycin, Rat "