绿色荧光蛋白裸小鼠的培育及应用进展

doi:10.3969/j.issn.1674-5817.2016.02.016

摘要/Abstract

摘要： 绿色荧光蛋白(GFP)裸小鼠最初是为肿瘤研究而培育,是同时具有T淋巴细胞缺陷和系统表达GFP基因的裸小鼠。近20年来,学者们对其生物学特性进行了广泛而深入的研究,为该小鼠模型的应用奠定了基础。

Abstract: It reported here that the development and application of the transgenic green fluorescent protein (GFP) nude mouse with ubiquitous GFP expression. BALB/c nude mouse with GFP were bred for cancer research initially, in which were deficient in T lymphocytes. In the last decades, researchers had studied vastly and deeply the biological characteristics and application of BALB/c nude mouse with GFP. The application of GFP nude mouse model should greatly expanded our knowledge in science research.

Key words: Green fluorescent protein (GFP), Nude mouse, Immunologic characteristics, Tumor models

中图分类号:

Q95-33

方天, 恽时锋. 绿色荧光蛋白裸小鼠的培育及应用进展[J]. 实验动物与比较医学, 2016, 36(2): 152-156.

FANG Tian, YUN Shi-feng. Progress on Development and Application of BALB/c Nude Mouse with GFP[J]. Laboratory Animal and Comparative Medicine, 2016, 36(2): 152-156.

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