GK糖尿病大鼠发病机理的研究进展

doi:10.3969/j.issn.1674-5817.2011.02.018

摘要/Abstract

摘要： 自发II型糖尿病GK大鼠与人类非肥胖型II型糖尿病进展极为相似。GK大鼠主要特点为胰岛素分泌受损、胰岛β细胞数量减少,空腹血糖升高,肝糖原生成增多,肌肉和脂肪组织中度胰岛素抵抗等特点。文章主要从GK大鼠遗传学特征、胰腺的形态学异常及胰腺、肝脏、肌肉和脂肪组织的细胞因子的变化以及它们与II型糖尿病的发病机理的关系的研究进展作一综述。

关键词: Goto-Kakizaki大鼠, II型糖尿病, 发病机理, 进展

Abstract: The Goto-Kakizaki (GK) rat, one of the the best characterized animal models of spontaneous non-obese T2D, has similar progressive course with human. This animal is characterized by impaired glucose-induced insulin secretion, decreased beta cell mass, raised fasting blood glucose level, hepatic glucose overproduction and moderate insulin resistance in muscles and adipose tissues. Here, we review studies concerning genetic characterization, abnormal islet morphology, cytokines changes in some major tissues, such as islet, liver, muscles and adipose tissues, and the relationship of these changes and T2D etiopathology.

Key words: Goto-Kakizaki rat, type 2 diabetes, etiopathology, development

中图分类号:

Q95-33

赵先哲, 乔伟伟. GK糖尿病大鼠发病机理的研究进展[J]. 实验动物与比较医学, 2011, 31(2): 140-146.

ZHAO Xian-zhe, QIAO Wei-wei. The Research Advancement on Etiopathology of Goto-Kakizaki Diabetic Rat[J]. Laboratory Animal and Comparative Medicine, 2011, 31(2): 140-146.

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