Abstract: Objective To observe the therapeutic effects of Shuangju Particles on experimental hyperplasia of mammary glands in rat and rabbit. Method The model of mammary gland hyperplasia was established by injection of estradiol benzoatics in this experiment, To observe the treatment of shuangju particles on mammary gland hyperplasia in rat and rabbit. Result The Shuangju particles can inhibit mammary enlargement caused by estrogen, reduce the level of E₂ in serum of rats and rabbit with mammary gland hyperplasia, increase the content of progesterone, reduce the number of lobular, acinar,the cell proliferative layer and the degree of mammary duct expansion. Meanwhile, the experiment of egg white induced foot swelling showed that it also has significant anti-inflammatory effect. Conclusion Shuangju Particles has preventive and therapeutic effects on experimental hyperplasia of mammary glands in rats and rabbit,and it may be used to treat disease of mammary gland hyperplasia in clinical.

Key words: Shuangju Particles, Hyperplasia of Mammary gland, Rats, Rabbit