实验动物学科教融合体系的思考与实践：以山东中医药大学为例

doi:10.12300/j.issn.1674-5817.2025.176

实验动物与比较医学 ›› 2026, Vol. 46 ›› Issue (4): 604-610.DOI: 10.12300/j.issn.1674-5817.2025.176

实验动物学科教融合体系的思考与实践：以山东中医药大学为例

李自发¹, 刘珊², 孙伟¹, 赵峰¹, 魏盛³, 李琴¹, 徐凯勇¹()

^1.山东中医药大学实验中心, 济南 250355
^2.山东中医药大学创新创业学院, 济南 250355
^3.山东中医药大学科研处, 济南 250355

收稿日期:2025-10-27 修回日期:2026-01-30 出版日期:2026-08-25 发布日期:2026-08-22
通讯作者: 徐凯勇（1980—），男，硕士，高级实验师，研究方向：药物干预病证模型机制研究。E-mail： xkychina@163.com。ORCID：0009-0000-6308-9645
作者简介:李自发（1977—），男，本科，高级实验师，研究方向：动物模型与比较医学。E-mail： zifa_0611@163.com
基金资助:
山东中医药大学教育教学研究课题（实验教学专项）重点项目“科研伦理共支撑学科融合同向前——以《医学实验动物学概论》课程为例建立科教融合教学体系”(SYZD2024005);山东中医药大学教育教学研究课题（实验教学专项）一般项目“基于实验动物中心管理的斑马鱼创新实验室建设与实验教学创新实践”(SYYB2024007);山东中医药大学2025年教育教学研究课题“大学生创新训练实践路径研究”(Y202520)

Reflections on Building a Science-Education Integration System for Laboratory Animal Science: A Case Study of Shandong University of Traditional Chinese Medicine

LI Zifa¹, LIU Shan², SUN Wei¹, ZHAO Feng¹, WEI Sheng³, LI Qin¹, XU Kaiyong¹()

^1.Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
^2.College of Innovation and Entrepreneurship, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
^3.Office of Academic Research, Shandong University of Traditional Chinese Medicine, Jinan 250355, China

Received:2025-10-27 Revised:2026-01-30 Published:2026-08-25 Online:2026-08-22
Correspondence to: XU Kaiyong (ORCID: 0009-0000-6308-9645), E-mail: xkychina@163.com

摘要/Abstract

摘要：

在教育部“新医科”建设背景下，高等医学教育面临重构人才培养体系的时代要求。本文以山东中医药大学实验动物学课程为例，系统探讨了如何构建一个科教深度融合的教学体系，以破解传统教学中理论与实践脱节、学生创新思维不足等问题。该体系的构建立足于三大支柱：一是组建了一支多学科交叉的高水平师资团队，有力支撑了教学创新；二是依托山东中医药大学实验动物中心及中医药防治重大脑疾病山东省工程研究中心，保障了创新所需的硬件设施；三是通过“多学科、多形式、多层次”融合，系统性重构了教学内容与模式。改革成效显著，尤其体现在学生科研创新能力的提升：在大学生创新训练计划项目中，获批省级以上立项的比例从改革前的11.1%显著提升至41.6%；学生团队更是在全国大学生基础医学创新研究暨实验设计论坛、全国大学生医学创新大赛等国家级竞赛中斩获金奖和银奖。此外，本团队教师担任人民卫生出版社全国规划教材《实验动物学》主编、编委，标志着本团队的课程建设成果获得了全国同行的认可。实践证明，该科教融合体系能有效将科研资源转化为育人优势，为培养具备扎实实践技能与前沿创新素养的中医药拔尖人才提供了行之有效的路径，也为同类院校的教学改革提供了可资借鉴的范例。

关键词: 实验动物学, 科教融合, 教学体系建设, 中医特色

Abstract:

Against the backdrop of the "New Medical Education" initiative by the Ministry of Education, higher medical education faces an urgent need to reconstruct its talent cultivation system. Taking the Laboratory Animal Science course at Shandong University of Traditional Chinese Medicine as an example, this paper systematically explores how to construct a teaching system featuring deep integration of scientific research and education, aiming to address the disconnection between theory and practice and the lack of innovative thinking among students in traditional teaching. The construction of this system is based on three pillars: first, the establishment of a high-level, interdisciplinary faculty team that strongly supports teaching innovation; second, reliance on the Laboratory Animal Center of Shandong University of Traditional Chinese Medicine and the Shandong Provincial Engineering Research Center for Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine to provide the necessary facilities; third, a systematic restructuring of teaching content and modes through the "multidisciplinary, multi-format, and multilevel" integration approach. The reform has yielded remarkable results, particularly evident in the increase in students' scientific research and innovation capabilities: the proportion of student projects approved at the provincial level or above in undergraduate innovation training programs significantly increased from 11.1% before the reform to 41.6%. Furthermore, student teams have won gold and silver awards in national competitions such as the "National Undergraduate Innovation Forum for Basic Medical Sciences and Experimental Design" and the "National College Students' Medical Innovation Competition". Additionally, the teaching team's faculty members serving as chief editors and editorial board members of the national planning textbook Laboratory Animal Science published by People's Medical Publishing House mark the nationwide recognition of the course construction achievements. Practice has shown that this integrated system effectively transforms scientific research resources into educational advantages, providing an effective pathway for cultivating top-notch talents in traditional Chinese medicine with solid practical skills and advanced innovative capabilities. It also offers a replicable model for teaching reforms in peer institutions.

Key words: Laboratory animal science, Integration of science and education, Teaching system development, Traditional Chinese medicine characteristics

中图分类号:

G642

李自发,刘珊,孙伟,等. 实验动物学科教融合体系的思考与实践：以山东中医药大学为例[J]. 实验动物与比较医学, 2026, 46(4): 604-610. DOI: 10.12300/j.issn.1674-5817.2025.176.

LI Zifa,LIU Shan,SUN Wei,et al. Reflections on Building a Science-Education Integration System for Laboratory Animal Science: A Case Study of Shandong University of Traditional Chinese Medicine[J]. Laboratory Animal and Comparative Medicine, 2026, 46(4): 604-610. DOI: 10.12300/j.issn.1674-5817.2025.176.

图/表 2

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序号 Number	评价项目 Evaluation item	实验方法 Experimental method	考察目标 Assessment objective
1	快感缺失	糖水偏好实验	评估奖赏系统功能、反映动物对奖赏刺激的反应能力
2	行为绝望	强迫游泳实验	检测抑郁样行为，反映动物面对不可逃避压力时的被动应对策略
3	活动量	旷场实验	测定自主运动能力，反映动物在新环境中的自发活动和探索行为
4	应激反应	体重变化率、肾上腺系数	属于客观生理参数，与行为学检测形成互补，评估生理应激水平

序号 Number	评价项目 Evaluation item	实验方法 Experimental method	考察目标 Assessment objective
1	快感缺失	糖水偏好实验	评估奖赏系统功能、反映动物对奖赏刺激的反应能力
2	行为绝望	强迫游泳实验	检测抑郁样行为，反映动物面对不可逃避压力时的被动应对策略
3	活动量	旷场实验	测定自主运动能力，反映动物在新环境中的自发活动和探索行为
4	应激反应	体重变化率、肾上腺系数	属于客观生理参数，与行为学检测形成互补，评估生理应激水平

实验动物学科教融合体系的思考与实践：以山东中医药大学为例

Reflections on Building a Science-Education Integration System for Laboratory Animal Science: A Case Study of Shandong University of Traditional Chinese Medicine

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