常规实验操作对啮齿类动物应激系统的影响

doi:10.3969/j.issn.1674-5817.2014.03.018

实验动物与比较医学 ›› 2014, Vol. 34 ›› Issue (3): 255-258.DOI: 10.3969/j.issn.1674-5817.2014.03.018

• 综述 • 上一篇

常规实验操作对啮齿类动物应激系统的影响

韦姗姗^1,2, 杨合金³, 屈会化^1,2, 赵琰^1,2, 王庆国^1,2

1.北京中医药大学基础医学院, 北京, 100029;
2.北京中医药大学“ 经典方剂的应用基础研究” 创新团队, 北京100029;
3.云南省药物研究所, 昆明650111

收稿日期:2013-11-12 出版日期:2014-06-25 发布日期:2014-06-25
作者简介:韦姗姗(1987-), 女, 研究方向: 中医临床基础,E-mail: weiss814@163.com
基金资助:
国家重点基础研究发展计划(“973”计划) 2011年资助项目(No.2011CB505101)

Experimental Operations Induced Stress in Rodents

WEI Shan-shan^1,2, YANG he-jin³, QU Huihua^1,2, ZHAO Yan^1,2, WANG Qing-guo^1,2

1. College of Basic Medicine, Beijing University of Chinese Medicine, Beijing 100029,China;
2. “Classical Prescription Application Foundation Research” Innovation Team, Beijing University of Chinese Medicine, Beijing 100029,China;
3. Yunnan Institute Of Materia Medica, Kunming 650111, China

Received:2013-11-12 Online:2014-06-25 Published:2014-06-25

摘要/Abstract

摘要： 已经证实,常规实验操作,如抓取、灌胃、麻醉、采血、束缚、搬运等,会引起实验动物的应激反应,导致与应激有关的生理指标发生显著的变化,这在一定程度上对实验结果产生干扰。因此明确常规实验操作对实验动物的具体影响尤为重要。但由于这些操作的普遍性,这种影响常常被研究者所忽视。本文分别从以上方面对啮齿类动物应激系统的影响进行综述。

关键词: 实验操作, 啮齿类动物, 应激

Abstract: The routine experimental operations ,such as handling, orogastric gavage, anaesthesia, blood collection, restrict, transport, etc . can induce stress in animals. The operations impact on some parameters correlated with stress and metabolic, which have a probable influence on experiment results. However, the impacts are usually ignored by researchers due to the pervasiveness of the operations. This article described the impacts respectively.

Key words: Experimental operations, Rodent, Stress

中图分类号:

Q95-33

韦姗姗, 杨合金, 屈会化, 赵琰, 王庆国. 常规实验操作对啮齿类动物应激系统的影响[J]. 实验动物与比较医学, 2014, 34(3): 255-258.

WEI Shan-shan, YANG he-jin, QU Huihua, ZHAO Yan, WANG Qing-guo. Experimental Operations Induced Stress in Rodents[J]. Laboratory Animal and Comparative Medicine, 2014, 34(3): 255-258.

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常规实验操作对啮齿类动物应激系统的影响

Experimental Operations Induced Stress in Rodents

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