The Research Progress of Pathological Characteristics of Animal Models with Heart Failure with Ejection Fraction Preservation

doi:10.3969/j.issn.1674-5817.2020.01.013

Abstract

Abstract: Heart failure with ejection fraction preservation (HFpEF) is the main type of heart failure at present, but there is no effective prevention and treatment method. To develop new drugs on preventingHFpEF and elucidate its pharmacodynamic and pharmacological characteristics, it is urgent to establish animal models that can reflect the pathogenesis and pathological characteristics of HFpEF. We reviewed the animal models that can reflect the pathological characteristics of HFpEF. And we expect more representative HFpEF animal models can be created further.

Key words: Heart failure with ejection fraction preservation (HFpEF), Animal models, Pathological mechanism, Research progress

CLC Number:

Q95-33

DONG Guoju, LIU Jiangang, Guan Jie. The Research Progress of Pathological Characteristics of Animal Models with Heart Failure with Ejection Fraction Preservation[J]. Laboratory Animal and Comparative Medicine, 2020, 40(1): 74-79.

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