Abstract: Currently, multiple drugs and other therapies are used for diabetic wounds, including Chinese herbs, Western medicine, biological agents, and physical therapy, these agents have been shown to be associated with favorable clinical outcomes, however, their long-term efficacy needs to be further improved. A diabetic wound is the result of an interaction among multiple cells and cytokines, and therefore a single treatment method is often ineffective. On the basis of establishing stable and reliable animal models, the mechanism underlying each treatment method can be clarified through pharmacological research, providing a basis for combined clinical application and improved clinical outcomes. In this paper, the scientific literature related to diabetic animal models with skin injury from the last 24 years was collected, and the factors involved in animal model preparation and treatment data were statistically analyzed to provide references for improving the modeling efficiency and scientifically evaluating the effectiveness of treatment methods.

Key words: Diabetes, Animal models, Skin injury, Modeling factors, Treatment methods