Microglia and Anxiety: The Key Role and Mechanism

doi:10.3969/j.issn.1674-5817.2020.01.014

Abstract

Abstract: Recently, the incidence of anxiety has increased, but its pathogenesis is still unclear and treatment results are unsatisfied. Microglia (MG) are innate immune cells which are widely distributed in the central nervous system (CNS) and participate in the immune process of CNS. Increasing studies have shown that over-activated MG play an important role in the development of anxiety. Stress-activated MG are divided into 2 polarization phenotypes: Classical activated MG (M1) and alternatively activated microglia (M2) according to their functions. M1 can promote the development of anxiety by inducing immune disorders, affecting neurotransmitter release, altering neuronal signaling, and activating endocrine systems; while M2 have the effects of promoting nerve regeneration, angiogenesis, remyelination to relieve anxiety.The study of MG function is expected to find a new perspective in mechanism of anxiety, and inducing the transformation of MG to M2 may be potentially benefited for the treatment of anxiety.

Key words: Microglia (MG), Anxiety, Neurotransmitter, Inflammation, Endocrine

CLC Number:

749.72Q95-33

LU Dengcheng, SHI Anhua, CHEN Shuai, WEI ShanShan. Microglia and Anxiety: The Key Role and Mechanism[J]. Laboratory Animal and Comparative Medicine, 2020, 40(1): 80-86.

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