Review of Spontaneous and Drug-related Islet Fibrosis in Rats

doi:10.3969/j.issn.1674-5817.2019.03.014

Abstract

Abstract: Islet fibrosis is a common spontaneous disease in rats. The incidence increased with age as well as that of male was higher than female. The pathogenesis and mechanism of this disease have not been conclusive yet. Many drugs could also induce or increase fibrosis in pancreatic islets in rats. Vascular injury in islet was considered to be associated with the occurrence of the disease. This article summarizes the research of spontaneous and drug related pancreatic islet fibrosis in rats, and provides some references for experimental animal research and toxicological pathologists.

Key words: Rats, Islet fibrosis, Spontaneous, Drug-related

CLC Number:

Q95-33

ZHOU Fei, WANG Hao-an. Review of Spontaneous and Drug-related Islet Fibrosis in Rats[J]. Laboratory Animal and Comparative Medicine, 2019, 39(3): 249-252.

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