Laboratory Animal and Comparative Medicine ›› 2023, Vol. 43 ›› Issue (1): 44-52.DOI: 10.12300/j.issn.1674-5817.2022.069

• Development and Utilization of Laboratory Animal Resources • Previous Articles     Next Articles

Investigation on Biological Characteristics and Aging Phenotype of SHJH hr Mice

Huiqing TANG1(), Shufu CHANG2, Zhifeng YU3, Lei ZHANG3, Xiaoqian TAN1, Wei QU1, Liang LI1, Zhen QIAN1, Jianzhong GU1, Ping XU1()()   

  1. 1.Shanghai Jihui Laboratory Animal Care Co. , Ltd. , Shanghai 201611, China
    2.Zhongshan Hospital, Fudan University, Shanghai 200032, China
    3.Shanghai Key Laboratory of Orthopaedic Implant, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Received:2022-05-23 Revised:2022-09-21 Online:2023-02-25 Published:2023-03-09
  • Contact: Ping XU


Objective To measure and analyze biological characteristics and aging phenotype of SHJH hr mice and provide basic data for the application of the mouse model in aging mechanisms research and antiaging drug development. Methods With ICR mice of the same age as control group, the body mass growth data of SHJH hr mice at the age of 3 to 16 weeks, the reproduction ability of 1 to 4 fetuses and the life cycle of SHJH hr mice were measured. Blood routine (30 items) and serum biochemical indexes (25 items) of 6-week-old SHJH hr mice were measured. The venous blood of 8-week-old SHJH hr mice was collected for flow cytometry analysis to determine the content of immune cells. The aging bone structure of the cancellous bone and bone mineral density of SHJH hr mice aged 4, 8 and 26 weeks were measured by micro-CT. Histopathological changes of bone and joint of 8-week-old mice were observed. Results Compared with ICR mice, the female and male body mass of SHJH hr mice were significantly lower at the age of 16 weeks (P < 0.05), and the reproductive performance of female mice was low (P < 0.01) or did not have normal reproductive capacity. The shortest survival time of SHJH hr mice was 57 weeks and the longest was 71 weeks, which was shorter than those of normal ICR mice, showing obvious rapid aging phenomenon. At the same time, some physiological and biochemical indexes of blood and pathological changes of bone and cartilage tissues also showed the accelerated aging and abnormality of animal physiological functions. Conclusion SHJH hr mice have some biological characteristics of rapid aging as well as some physiological and pathological changes caused by aging.

Key words: Spontaneous rapid aging, Bio-characteristics, Aging phenotype, SHJH hr mice

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