关键词: Ⅱ型糖尿病动物模型, 糖基化终产物-肽, 醛糖还原酶, 血糖

Abstract: Objective The purpose of this study is to provide animal model of diabetes Ⅱ and basic data for studying the development principle of the diabetes and diabetic complication. Methods：The rat model of diabetes Ⅱ was made by fed with a diet enriched with energy and ip low-dose streptozotocin （STZ 30mg/kg）. The indexes related to the development of diabetic complication were detected. Results：The blood glucose level of treated rats was significantly higher than that of normal control rats,and the sensitivity to insulin was decreased. The level of advanced glyco-sylation end products-peptide （AGE-P） and lipoid peroxidation products malondialdehyde （MDA） in serum and the activity of aldose reductase（AR） in kidney of the diabetes model rats were remarkably increased, compared with whose of the control rats，whereas the superoxide dis-mutase （SOD） activity in serum of the models was significantly decreased. Conclusion：The diabetes Ⅱ rat model can be successfully established by fed with a diet enriched with energy and ip low-dose streptozotocin. The levels of indexes related to diabetic complication were changed. And this change may induce the development of diabetic complication.

Key words: Diabetes Ⅱ animal model, Advanced glycosylation end products-peptide （AGE-P）, Aldose reductase（AR） , Blood glucose