栀子黄色素类单体对糖尿病小鼠降血糖作用

doi:10.3969/j.issn.1674-5817.2018.05.011

实验动物与比较医学 ›› 2018, Vol. 38 ›› Issue (5): 387-389.DOI: 10.3969/j.issn.1674-5817.2018.05.011

栀子黄色素类单体对糖尿病小鼠降血糖作用

黎砚书, 徐丽瑛, 周艳艳, 吴金花, 丁琦, 李艳, 李玉云, 肖小华

江西省医疗器械检测中心,南昌 330029

收稿日期:2018-05-31 出版日期:2018-10-25 发布日期:2018-10-25
作者简介:黎砚书(1987-),女,硕士,助理研究员,主要从事药物药理、毒理及病理研究。E-mail:liyanshu0716@163.com
基金资助:
江西省卫生计生委科研项目(No.2014A029)

The Hypoglycemic Effect of Gardenia Yellow Monomers on Diabetic Mice

LI Yan-shu, XU Li-ying, ZHOU Yan-yan, DI Qi, LI Yan, LI Yu-yun, XIAO Xiao-hua

Jiangxi Supervision and Inspection Center of Medical Devices,Nanchang 330029,China

Received:2018-05-31 Online:2018-10-25 Published:2018-10-25

摘要/Abstract

摘要： 目的探讨栀子黄色素类单体对糖尿病小鼠降血糖的作用。方法采用四氧嘧啶制备糖尿病小鼠模型,测定栀子黄色素类单体对淀粉负荷和蔗糖负荷糖尿病小鼠血糖的影响。结果西红花苷Ⅰ100 mg/kg、西红花酸100 mg/kg和西红花苷Ⅲ50 mg/kg可显著降低淀粉负荷糖尿病小鼠血糖;西红花苷Ⅰ100 mg/kg、西红花酸50 mg/kg、100 mg/kg和西红花苷Ⅲ100 mg/kg可显著降低蔗糖负荷糖尿病小鼠血糖。结论栀子黄色素类单体西红花苷Ⅰ、西红花酸和西红花苷Ⅲ对淀粉负荷和蔗糖负荷糖尿病小鼠均有降血糖作用。

关键词: 栀子黄色素, 西红花苷Ⅰ, 西红花酸, 西红花苷Ⅲ, 降血糖

Abstract: Objective To explore the hypoglycemic effect of Gardenia yellow monomers on diabetic mice induced by alloxan monohydrate. Methods The effect of gardenia yellow monomers (crocin Ⅰ, crocin Ⅲ, crocetin) on blood sugar in diabetic mice with starch loading and sucrose loading was determined. Diabetic mice were prepared by intravenous injection of alloxan monohydrate. Results In comparing with model group, the blood sugar were significantly decreased in 100 mg/kg crocin Ⅰ, 100 mg/kg crocetin , 50 mg/kg crocin Ⅲ groups mice with starch loading. The blood sugar were significantly decreased in 100 mg/kg crocin Ⅰ, 50 mg/kg and 100 mg/kg crocetin , 100 mg/kg crocin Ⅲ groups mice with sucrose loading than the model mice. Conclusion Gardenia yellow monomers crocin Ⅰ, crocin and crocin Ⅲ all have hypoglycemic effect on starch loading and sucrose loading diabetic mice.

Key words: Gardenia yellow, Crocin Ⅰ, Crocetin, Crocin Ⅲ, Hypoglycemic effect

中图分类号:

Q95-33

黎砚书, 徐丽瑛, 周艳艳, 吴金花, 丁琦, 李艳, 李玉云, 肖小华. 栀子黄色素类单体对糖尿病小鼠降血糖作用[J]. 实验动物与比较医学, 2018, 38(5): 387-389.

LI Yan-shu, XU Li-ying, ZHOU Yan-yan, DI Qi, LI Yan, LI Yu-yun, XIAO Xiao-hua. The Hypoglycemic Effect of Gardenia Yellow Monomers on Diabetic Mice[J]. Laboratory Animal and Comparative Medicine, 2018, 38(5): 387-389.

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栀子黄色素类单体对糖尿病小鼠降血糖作用

The Hypoglycemic Effect of Gardenia Yellow Monomers on Diabetic Mice

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