PI3K/Akt和AMPK信号通路在运动诱导的啮齿动物骨骼肌内GLUT4转位和表达中的作用

doi:10.3969/j.issn.1674-5817.2017.01.017

摘要/Abstract

摘要： 骨骼肌在葡萄糖稳态中扮演重要作用,葡萄糖转运体4(glucose transporter 4,GLUT4)作为骨骼肌内最主要的葡萄糖转运蛋白,其转位和表达的变化与胰岛素抵抗的发生密切相关。本文综述了近年来关于啮齿动物骨骼肌内GLUT4转位和表达的运动激活以及磷脂酰肌醇-3-激酶(phosphatidylinositol 3-kinases,PI3K)/蛋白激酶B(protein kinase B,Akt)和腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)信号通路介导运动改善骨骼肌葡萄糖摄取的研究进展,旨在为全面了解和明确运动影响啮齿动物骨骼肌内GLUT4转位和表达的机制。

关键词: 骨骼肌, 运动, 胰岛素抵抗, 葡萄糖转运体4(GLUT4), 磷脂酰肌醇-3-激酶(PI3K)

Abstract: Skeletal muscles play an important role in glucose homeostasis. The translocation and expression changes of glucose transporter 4 (GLUT4) as one of the most important glucose transporter proteins in skeletal muscle are closely associated with insulin resistance. This paper reviewed the recent research progress on the exercise-induced translocation and expression of GLUT4 as well as the improvement of exercise-induced glucose uptake by phosphatidylinositol 3-kinases (PI3K) / protein kinase B (Akt) and AMP-activated protein kinase (AMPK) signaling pathways in rodent skeletal muscle. The purpose of this paper is to clearly understand the mechanism underlying GLUT4 translocation and expression in rodent skeletal muscles.

Key words: Skeletal muscle, Exercise, Insulin resistance, Glucose transporter 4 (GLUT4), Phosphatidylinositol 3-kinases (PI3K), Protein kinase B (Akt), AMP-activated protein kinase (AMPK)

中图分类号:

Q95-33

张云丽, 王林, 刘铁民. PI3K/Akt和AMPK信号通路在运动诱导的啮齿动物骨骼肌内GLUT4转位和表达中的作用[J]. 实验动物与比较医学, 2017, 37(1): 76-82.

ZHANG Yun-li, WANG Lin, LIU Tie-min. PI3K/Akt and AMPK Signaling Pathway and Effect of Exercise on Rodent Skeletal Muscle GLUT4 Translocation and Expression[J]. Laboratory Animal and Comparative Medicine, 2017, 37(1): 76-82.

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